Lectins in Immunohematology

Given the Lectin, Identify Antigen Inhibited By, and Serologic Specificity

α-L-fucose

Anti-H

Ulex europaeus

α-L-fucose

Anti-H

Lotus tetragonolobus

Terminal α-N-acetyl-D-galactosamine

Anti-A, Anti-Tn, Anti-Cad

Dolichos biflorus

α-N-acetyl-D-galactosamine

Anti-A, Anti-Tn, Anti-Cad

Helix pomatia

α-D-galactose

Anti-B, Anti-Tn

Griffonia simplicifolia I

α- or β-N-acetyl-D-galactosamine

Anti-Tk

Griffonia simplicifolia II

• Ulex europaeus

• Lotus tetragonolobus

• Dolichos biflorus

• Helix pomatia

• Griffonia simplicifolia I

• Griffonia simplicifolia II

Lectin for ABO Antigens

NO ANTIGEN INHIBITED

Anti-M

Iberis amara

O-linked N blood group tetrasaccharide

Anti-N

Vicia graminea

• Iberis amara

• Vicia graminea

Lectin for other blood group antigens

β-D-galactose

Anti-T, Anti-Tk, Anti-Th, Anti-Tx

Arachis hypogaea

• Glycine soja (max): Anti-T, Anti-Tn

• Leonurus cardiaca: Anti-Cad specific at appropriate dilution

• Salvia horminum: Anti-Tn, Anti-Cad (Separable)

• Salvia sclarea: Anti-Tn specific

α-N-acetyl-D-galactosamine

Galactose (β1,3) N-acetyl-galactosamine

Anti-T, Anti-Th

Vicea cretia