Diseases of the vesicular glands are rare but can include hypoplasia, aplasia, acute seminal vesiculitis, and chronic seminal vesiculitis. Acute seminal vesiculitis is characterized by pain, enlargement, and firmness, with the presence of fibrin or purulent exudate in the semen. Chronic seminal vesiculitis is associated with persistent purulent exudate, fibrosis, enlargement, and loss of lobulation. It is typically not painful.