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IgA
neutralization
major secretory antibody
IgD
b cell receptor
activate b cells
IgE
fc binds and activates mast cells/basophils
parasite immunity
IgG
neutralizatoin, agglutination, complement activation, opsonization, cell mediated cytotoxicity
major circulating antibody
crosses placenta
IgM
neutralization, complement activation, agglutination
first antibody to appear