Negative selection and self-tolerance revisited
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Last updated 7:53 PM on 4/10/25
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4 Terms
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How does central tolerance work?
removes self-reactive T and B cells through apoptosis during negative selection.
2
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What mechanisms are involved in peripheral tolerance?
involves regulatory T cells and the need for helper T cells to activate B cells.
3
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What happens to T and B cells that don't receive a costimulatory signal?
They become anergic, meaning they are inactivated and do not respond.
4
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