2. Quaternary structure. Mechanisms maintaining the conformation of proteins. Relation between the structure and the function of proteins – medical importance: defects in receptors (familial hypercholesterolemia, diabetes insipidus); diseases due to impaired conformation (prion disease, Alzheimer’s disease); molecular diseases (sickle cell anemia); defects in the post-translational modification of proteins (scurvy and glycated hemoglobin). Structure of hemoglobin. Isoelectric point, precipitation of protein. Denaturation. Electrophoresis. Methods for protein examination – electrophoresis, chromatography, etc. Electrophoresis of plasma proteins – fractions
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