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Modern Civilizations — Semester 2 Exam Study Guide Exam Date: May 22 Format: Bubble Sheet Questions: 123 total • 50 Vocabulary/Matching • 50 Multiple Choice • 16 Map Skills • 7 Document-Based Questions ⸻ SECTION A — GEOGRAPHY SKILLS Key Vocabulary Cardinal Directions • North • South • East • West Shown on a compass rose. Intermediate Directions • Northeast • Northwest • Southeast • Southwest Latitude Imaginary lines that run east-west and measure distance north or south of the Equator. Longitude Imaginary lines that run north-south and measure distance east or west of the Prime Meridian. Projection A flat map representation of Earth. Scale Shows distance on a map. Distortion When map shapes, sizes, or distances are changed because Earth is round. ⸻ 5 Themes of Geography 1. Location Where a place is. 2. Place What a place is like. 3. Movement How people, goods, and ideas move. 4. Region An area with common features. 5. Human-Environment Interaction How people affect and adapt to the environment. ⸻ Continents & Oceans 7 Continents • North America • South America • Europe • Asia • Africa • Australia • Antarctica 5 Oceans • Pacific • Atlantic • Indian • Arctic • Southern ⸻ CHAPTER 23 — SCIENTIFIC REVOLUTION & AGE OF EXPLORATION Section 1 — Scientific Revolution Key Vocabulary Geocentric Theory Earth is the center of the universe. Heliocentric Theory The sun is the center of the solar system. Elliptical Oval-shaped planetary orbits. Scientific Method Organized process of observation, testing, and experimentation. Scientific Rationalism Using reason and logic to understand the world. ⸻ Important People Galileo Galilei Used a telescope to support heliocentric theory. Isaac Newton Developed laws of motion and gravity. Nicolaus Copernicus Proposed heliocentric theory. René Descartes Believed truth comes through reason. Robert Hooke Studied cells using microscopes. Sir Francis Bacon Promoted experimentation and observation. ⸻ Comprehension & Concepts Educational ideas Muslim scholars adopted from India • Mathematics • Astronomy • Number system (including zero) How were cells discovered? Scientists used microscopes to observe tiny living structures. Who led the study of cells? Robert Hooke ⸻ Section 2 — The Age of Exploration Key Vocabulary Caravel Fast, maneuverable sailing ship used by explorers. Colony Land controlled by another country. Exploit To use resources for benefit or profit. Quinine Medicine used against malaria. Rivalry Competition between nations. Smallpox Deadly disease spread to Native Americans. ⸻ Important People & Places Christopher Columbus Sailed for Spain and reached the Americas in 1492. Columbian Exchange Transfer of plants, animals, diseases, and ideas between Europe and the Americas. Dutch East India Company Controlled trade in Asia. Ferdinand II of Aragon and Isabella I of Castile Sponsored Columbus’s voyage. Prince Henry the Navigator Encouraged Portuguese exploration. ⸻ Comprehension & Concepts Who was Prince Henry the Navigator? A Portuguese prince who funded exploration schools, maps, and voyages. Why was the Caravel important? • Faster ship • Easier to steer • Could sail against the wind • Allowed longer ocean voyages ⸻ Section 3 — European Empires Key Vocabulary Conquistador Spanish conqueror in the Americas. Plantation Large farm using forced labor. Racism Belief that one race is superior. Triangular Trade Trade route connecting Europe, Africa, and the Americas. Middle Passage Brutal voyage transporting enslaved Africans to the Americas. ⸻ Important People & Places Atahualpa Last Inca emperor defeated by Spain. Francisco Pizarro Conquered the Inca Empire. Hernán Cortés Conquered the Aztec Empire. Pedro Álvares Cabral Claimed Brazil for Portugal. Tenochtitlan Capital of the Aztec Empire. ⸻ Comprehension & Concepts Describe the invasion of Mexico • Hernán Cortés led Spanish conquistadors. • The Aztecs were led by Montezuma. • Spanish had guns, horses, steel weapons, and Native allies. • Smallpox weakened the Aztecs. Conditions of the Middle Passage • Crowded ships • Disease • Starvation • Abuse and death Achievements of Portugal • Explored African coast • Opened sea routes to Asia • Built trading empire ⸻ CHAPTER 24 — ENLIGHTENMENT & REVOLUTIONS Section 1 — The Age of Reason Key Vocabulary Absolute Monarch King or queen with total power. Divine Right Belief that rulers receive power from God. Natural Rights Basic rights all people are born with. Enlightened Despot Ruler who accepted Enlightenment ideas. Laissez-faire Government should not interfere in economy. Free Enterprise Businesses operate with little government control. Philosophe French Enlightenment thinker. ⸻ Important People John Locke Believed people have natural rights. Montesquieu Supported separation of powers. Voltaire Supported freedom of speech and religion. Jean-Jacques Rousseau Believed government should follow the will of the people. Mary Wollstonecraft Supported women’s rights and education. Adam Smith Wrote about free-market economics. Louis XIV Example of an absolute monarch. Catherine the Great Enlightened despot of Russia. Frederick the Great Enlightened ruler. Joseph II Made reforms based on Enlightenment ideas. ⸻ Comprehension & Concepts What group applied science ideas to government? The philosophes. Why did philosophes think justice systems were unfair? Punishments were cruel and laws treated social classes unequally. ⸻ Section 2 — Revolutions on Three Continents Key Vocabulary Bourgeoisie Middle class. Jacobins Radical French Revolution group. Declaration of Independence American colonies’ statement of freedom from Britain. Declaration of the Rights of Man and of the Citizen French document declaring equality and rights. ⸻ Important People Thomas Jefferson Main writer of the Declaration of Independence. Louis XVI French king executed during the Revolution. Napoleon Bonaparte Rose to power after the French Revolution. Simón Bolívar Helped liberate Venezuela and other nations. José de San Martín Helped free South American countries from Spain. Toussaint Louverture Led Haitian independence movement. ⸻ Comprehension & Concepts Who fought for Venezuela’s independence? Simón Bolívar Why were the Articles of Confederation replaced? The national government was too weak. ⸻ CHAPTER 25 — INDUSTRIALIZATION, NATIONALISM & IMPERIALISM Section 1 — Industrial Revolution Key Vocabulary Industrialize Develop factories and machines. Urbanization Growth of cities. Labor Union Workers organized for better conditions. Push-Pull Factor Reasons people leave or move to places. Socialism Government control of economy to help society. Communism Classless society where property is shared. Woman Suffrage Women’s right to vote. ⸻ Important People Eli Whitney Invented the cotton gin. Karl Marx Created communist ideas. Ellis Island Main immigration station in the U.S. ⸻ Comprehension & Concepts Three ways Industrial Revolution changed society • More factories • Urbanization • Faster transportation • More goods produced • Growth of middle class Push factors affecting immigration • Poverty • Famine • War • Lack of jobs ⸻ Section 2 — Nationalism Around the World Key Vocabulary Nationalism Strong pride and loyalty to one’s nation. Nation-State Country with one national identity. Militarism Building up armed forces. Republic Government where citizens elect leaders. Dictator Leader with total control. ⸻ Important People Otto von Bismarck Unified Germany under Prussian leadership. Giuseppe Garibaldi Helped unify Italy. Meiji Emperor Led modernization of Japan. ⸻ Comprehension & Concepts Problems after Latin American independence • Political instability • Weak economies • Dictatorships • Social inequality Who unified Germany? Otto von Bismarck How did the Meiji Restoration transform Japan? • Modern industry • Modern military • Western education and technology ⸻ Section 3 — The New Imperialism Key Vocabulary Imperialism Strong nations taking control of weaker regions. Direct Rule Foreign country controls government directly. Missionary Person spreading religion. Sepoy Indian soldier serving Britain. Raj British rule in India. ⸻ Important Places & Events Berlin Conference European nations divided Africa. East India Company Controlled trade and territory in India. French Indochina French-controlled region in Asia. ⸻ CHAPTER 26 — WORLD AT WAR Section 1 — World at War Key Vocabulary Alliance Agreement between countries for support. Stalemate No side can win. Trench Warfare Fighting from dug trenches. U-boat German submarine. Bolsheviks Russian revolutionary communist group. Treaty of Versailles Treaty ending WWI. Triple Alliance Germany, Austria-Hungary, Italy. Triple Entente Britain, France, Russia. League of Nations International peace organization after WWI. ⸻ Important People Vladimir Lenin Leader of Bolsheviks. Karl Marx Inspired communist beliefs. ⸻ Comprehension & Concepts What triggered WWI? Assassination of Archduke Franz Ferdinand. Immediate effect of WWI on Russia Economic hardship and revolution. Why was WWI a total war? Entire economies and civilians supported the war effort. How did Bolsheviks change Russia’s war policy? Russia withdrew from WWI. Trench warfare resulted from what technology? Machine guns and modern artillery. ⸻ Section 2 — Between the Wars Key Vocabulary Fascism Dictatorship emphasizing nationalism and obedience. Propaganda Biased information used to influence people. Reparations Payments for war damages. Totalitarian Government with total control. Inflation Rising prices and weaker money value. ⸻ Important People Adolf Hitler Leader of Nazi Germany. Benito Mussolini Leader of Fascist Italy. Franklin D. Roosevelt Led U.S. during Great Depression and WWII. Joseph Stalin Communist dictator of USSR. ⸻ Comprehension & Concepts Conditions caused by Great Depression • Unemployment • Poverty • Bank failures • Economic collapse What kind of dictatorships did Hitler and Mussolini create? Fascist dictatorships. ⸻ Section 3 — World War II Key Vocabulary Appeasement Giving in to avoid conflict. Blitzkrieg “Lightning war” using fast attacks. Genocide Deliberate killing of a people group. Holocaust Murder of six million Jews during WWII. Ration Limit supplies during wartime. Atomic Bomb Extremely powerful nuclear weapon. ⸻ Important Places & People Pearl Harbor Japanese attack brought U.S. into WWII. Hiroshima First atomic bomb dropped. Nagasaki Second atomic bomb dropped. Winston Churchill Led Britain during WWII. ⸻ Comprehension & Concepts Which event broke German defenses in the west? D-Day invasion (Normandy invasion)

MMiPeople Francesco Redi: scientist who tested spontaneous generation with rotting meat and maggot formation with an open container, sealed container, and gauze-covered container, and refuted spontaneous generation Needham: scientist who tested spontaneous generation with boiling chicken broth, sealing the container, and waiting a few days to assess for microbial growth, and supported spontaneous generation Spallanzani: scientist who tested spontaneous generation with further testing, Needham’s experiment, and tested with an open and closed container that was later opened, and refuted spontaneous generation Louis Pasteur: scientist who used swan-neck flasks in his experiment and definitively refuted spontaneous generation Anthony van Leeuwenhoek: scientist who was the first to observe eukaryotic microbes, calling them “wee animalcule” Robert Hooke: coined the term “cell” when looking at cork Matthias Schleiden: observed cells in plant tissue Theodor Schwann: observed cells in animal tissue Rudolf Virchow and Robert Remark: observed cells dividing to make new cells (not mitosis) Hippocrates: suggested disease has natural causes Thucydides: advocated for evidence-based analysis of cause and effect and suggested immunity after observing plague survivors didn't get sick again Marcus Terentius Varro: the first to propose that things we cannot see cause disease Ignaz Semmelweis: physician who observed the spread of disease among patients in different sides of the hospital and instituted hand washing between patients to reduce the spread of disease from patient to patient via healthcare workers Joseph Lister: surgeon who observed post-surgical infection and instituted hand washing and sterilization of medical equipment with 5% phenol solution for less disease Robert Koch: scientist who developed Koch’s postulates to determine the cause of disease and had a rivalry with Louis Pasteur John Snow: questioned the London cholera outbreak and asked questions to the people who had been infected about where they had been and what they had eaten or drank, and noticed that everyone who had cholera used one of two water pumps Classification of microbes What are the 2 domains that are composed of all microbes? Bacteria and Archaea What domain of life is composed only of some microbes? Eukarya What types of microbes do not fit into the domains of life? Viruses and Prions Prions: unicellular organisms in the domains Bacteria and Archaea with no nucleus and have cell walls Viruses: acellular and domainless (not alive) Eukaryotes: unicellular OR multicellular organisms, in domain Eukarya, have a nucleus, have membrane-bound organelles, and include fungi, algae, protazoa, and helminths How many times bigger are bacteria than viruses? 100x A cell is around how many times bigger than an individual bacteria? 10x Cell structures Know the function, general location, and whether they are shared with eukaryotes (if yes similarities/differences) of the following structures: 1. Nucleoid: contains chromosome(s) and nuclear-associated proteins that are usually haploid and circular near the center of the cell, which hold the DNA genetic information without a membrane Eukaryotes = have a nucleus, are diploid and linear Prokaryotes = have nucleoid, are haploid and circular 2. Ribosomes: work with mRNA protein synthesis, made up of proteins and RNA, found in cytoplasm Eukaryotes: 80S, 60 large, 40 small (18S sequencing) Prokaryotes: 70S, 50 large, 30 small (16S sequencing) 3. Cytoplasm: fluid inner layer 4. Fimbriae: short, bristle-like projections for attachment to surfaces 5. Endospores: not all bacteria have, protect bacteria in a dormant state/ harsh environment, found inside bacteria, sporulation = the process of becoming dormant, germination = process of becoming active 6. Plasma membrane: semipermeable, composed of lipids and proteins, controls transport into and out of cell, most inner layer before cytoplasm (ex: facilitated diffusion, active transport, diffusion, endocytosis (Eukaryotes), sterols (Eukaryotes), and cholesterol (Eukaryotes) Same for Eukaryotes 7. Cell wall: protects against harsh changing environments and osmotic stress, contains peptidoglycan in bacteria, contains Gram + and Gram - Steps of Gram stain: dye with crystal violet, iodine (mordant), alcohol (decolorizer), and safranin red If mycobacteria complete an acid-fast stain Gram + has LTA an TA and one membrane Gram - has LPS and 2 membranes 8. Capsule: protective protein shell, outermost layer 9. Pilus: medium projection, adheres to surfaces, does DNA gene transfer 10. Flagellum: long protein projections made of flagellin for movement (ex: 1= monotrichous, one at each end = amphitrichous, many at one end = lophotrichous, many flagella all over the cell = peritrichous 11. Plasmid: circular, double-stranded DNA not part of the chromosome, and can have 1-100 of the same or different plasmids to help with gene transfer, antibiotic resistance, and virulence factors, found anywhere in the cytoplasm Not part of Eukaryotes 12. Inclusion: not all bacteria have, helps with the storage of nutrients and other materials, has protein shell, and is found in cytoplasm (ex: lipid droplets store fats, volutin stores inorganic phosphates, sulfur inclusions store sulfur, gas bubbles store gas for buoyancy in water, magnetosomes store metals for movement) Not part of Eukaryotes; instead, they have vesicles for storage All cellular microbes have what four (4) components? Cell Membrane, Cytoplasm, Ribosomes, and DNA What is the only component of all cells that viruses have? Cytoplasm Know/ be able to identify the shapes of bacteria Round shape: coccus Rod shape: bacillus Vibrio: curved rod shape Short rods with combo of coccus and bacillus: coccobacillus Wavy spiral shape: Spirillum Coiled spiral shape: Spirochete Microbial growth Phases of growth Lag Phase: bacteria gear up for replication by increasing cell size, metabolism, and protein synthesis Log Phase: exponential growth phase, where bacteria actively replicate and are most susceptible to antibiotics Stationary Phase: growth curve flatlines bc bacteria are dying at same rate of growth, begin survival mode and sporulation, produce secondary metabolites, and produce virulence factors, and are low on space, nutrients, and oxygen Death Phase: bacteria die at exponential rate, increase amount of toxic waste, release spores, some spontaneously lyse to feed others, and persister cells refuse to die How do microbes replicate? Through binary fission, fragmentation, budding, and sexually What is a biofilm? Communities of bacteria (steps: colonization, attachment, replication, make EPS with antibiotic resistance, EPS kick bacteria out to replicate somewhere else) How does quorum sensing work? Bacteria want to work together, so they secrete autoinducers, and when you activate enough receptors, they activate a response Growth requirements – classifications and adaptations 1. Oxygen requirements Obligate Aerobes: need O2 to survive Obligate Anaerobes: die in presence of O2 Faculative: mostly need O2 but can survive without it Microaerophiles: need O2 for survival but not atmospheric O2 (low levels) Aerotolerant: can survive with or without oxygen Capnophiles: like high CO2 and low O2 2. pH requirements Acidophiles: low pH (2-4), high H+ environments, efflux pumps to remove H+ ions, changes membrane composition to withstand low pH Neutrophiles: neutral pH (7), found within body Alkaliphiles: basic pH (9-10), modified lipid protein structures, modified electron transport system that use Na+ instead of H+, high OH- environment 3. temperature requirements Psychrophiles: like freezing temperatures a below 0-15 degrees, die at or above 20 degrees, found in cold lakes or the ocean floor, have hydrophobic proteins to increase flexibility, have decreased secondary stabilizing bonds Psychrotolerant: cold not ideal but wont kill them, live between 4-25 degrees (fridge temperature) Mesophiles: moderate temperatures, 20-40 degrees, grow in body Thermophiles: hot environments 50-80 degrees, hot springs, geothermal soil Hyperthermophiles: very hot environments 80-110 degrees, found in hydrothermal vents, increased saturation in membranes, increased stabilizing bonds, alter amino acids to prevent denaturation 4. osmolarity requirements Hypertonic: more water out Hypotonic: more water in Isotonic: equal water in and out Halotolerant: dont require salt but can grow in high salt environments Halophiles: love salt, found in ocean and salt lakes, have increased cytoplasmic glycerol, have efflux pumps for salt 5. barometric requirements Barophile: survive high atmospheric environments like the bottom of the ocean (something at top of mountain has low atmospheric pressure) Microbial Metabolism Means of generating energy (do the processes require oxygen?, which gives the most energy?) Glycolysis: does not require O2 bc it can be used during fermentation, used 2 ATP, makes 4 ATP, NET 2 ATP Kreb’s cycle: requires O2; NET after 1 round= 1ATP, 1 NADH, 1FADH2 (x2 for second round) Electron transport: requires O2, biggest payout of ATP with NET 34 ATP Photosynthesis: does not require O2 as it is a waste product, can do oxygenic and anoxygenic Microbial genetics DNA Replication – enzymes and functions DNA gyrase: unwinds DNA (enzyme) Helicase: unzips DNA (enzyme) Single-stranded binding proteins: bind to DNA so doesnt close back up (protein) Single-stranded binding proteins: bind to DNA so doesnt close back up (protein) DNA polymerase III: lay down new DNA nucleotides, synthesizes leading and lagging strands 5’ →3’(enzyme) DNA polymerase I: removes RNA primers (enzyme) DNA Ligase: seals RNA primers (enzyme) Topoisomerase 4: separates 2 circular chromosomes Transcription and translation – enzymes and function 1. RNA polymerase: turns DNA→ mRNA (transcription) 2. Ribosomes: 30S small, 50S large, 70S total 3. tRNA: A,P, and E sites, bacteria links transcription and translation bc no nucleus, has anticodon at opposite long 3’ end, high energy bond, same active translation process as Eukaryotes Be able to do DNA base pairing, transcription, and translation (given codon table) Also know differences between prokaryotic and eukaryotic Replication, transcription, and translation Genetic Diversity – how does this work? 1. Transformation: uptake of plasmid into different bacteria and is incorporated into its genetic material 2. Transduction: bacteriophage inserts its plasmid into a bacteria (virus that infects a bacteria) 3. Conjugation: like plasmid transfer (ex: rolling circle replication), “bacterial sex” 4