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Neuro-Ch 3/4
Neuro-Ch 3/4
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104 Terms
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1
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What makes up the CNS
brain and spinal cord
2
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What makes up the PNS
cranial nerves, spinal nerves, sensory organs (eyes, tongue, nose)
3
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Neurons are the \___________ of the nervous system
functional unit
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What is the function of neuron dendrites
receive electrical signals
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What is neuron soma and its job
body of neurons- responsible for the health of the neuron
6
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What is the job of neuron axons
longest part of the neuron- carries signal
7
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What is the function of neuron myelin sheaths
layer of fat that wraps axon, protects and speeds up signal
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What is the function of neuron axon terminals
make synaptic connections with another cell of effector cell
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In the brain, fiber types can be classified based on
where they go
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What fibers pass from one hemisphere to the other via the corpus callosum
commissural fibers
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What fibers pass from one lobe to another lobe in the same hemisphere
associative fibers- arcuate or U shaped fibers
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What fibers descend from the cerebral hemispheres to other areas of the CNS (mostly in internal capsule)
projection fibers
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After passing through the upper part of the brain stem, these fibers fan out and extend to the cerebral cortex
projection fibers
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What cells in the nervous system are capable of transmitting an impulse
neurons
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What cells in the nervous system are NOT capable of transmitting an impulse
neuroglial cells
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What are examples of neuroglial cells
astrocytes
oligodendrocytes
microglia
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What is an example of non-neuroglial cells that are not capable of transmitting an impulse
ependyma
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Glial cells support what
neuronal function- there are 10 for every neuron in the brain
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What role do microglia cells play
phagocytic/ scavenger
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What are the 3 main types of macroglia
astrocytes
oligodendrocytes
ependymal cells
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What is the function of astrocytes
metabolic support- scaffold for growing axons and BBB
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What is the function of oligodendrocytes
make myeline (1 can myelinate dozens of axons)
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What is the function of ependymal cells
produce CSF in the ventricles
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Schwann cells make myelin in what nervous system
PNS
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Oligodendrocytes make myelin in what nervous system
CNS
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Astrocytes as always attached to what
blood vessels
27
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Neurons are named based on the number of axons- what are the four main types of neurons
unipolar, bipolar, multipolar, and pseudounipolar
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Unipolar neurons have no dendrites and are found where
in glands for secretion and smooth muscle
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Bipolar neurons process like a dendrite and bring information into the cell body down the axon- they are found where
retina, somatic sensory (smell, touch)
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Most of the neurons in the body are
multipolar
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pseudounipolar neurons are typically found where
ANS, some cranial nerves
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PNS nerves can be classified as
motor, sensory, mixed, autonomic
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Nuclei are housed where
CNS- grey matter of the brain
34
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Ganglia are housed where
PNS- plexuses
35
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Connective tissue has three layers that are interconnected and contain free nerve endings that can be a source of pain- what are the layers
epineurium
perineurium
endoneurium
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What is the role of epineurium
surrounds, protects and enhances gliding between fasiculi
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What is the role of perineurium
pressurized container that surrounds the individual fascicles- selective barrier to diffusion, controls movement of fluid and ions
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What is the role of endoneurium
surrounds each nerve fiber and maintains fluid pressure (pressure increases with compression)
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Nerves are regularly \_______ and \_______ during movement
compressed and elongated
40
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Decreasing the diameter of intrinsic blood vessels does what
increases intraneural pressure
decreases blood flow within the nerve
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20-30mmHg adversely affects intraneural blood flow resulting in a
numb feeling
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50-70mmHg blood flow ceases resulting in
permanent myelin and axon damage
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peripheral nerves are surrounded by\_______ making them vulnerable to microtrauma
bone, fascia, and muscle
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Compression commonly occurs in locations where nerves pass through what
narrow anatomical openings (osseous tunnels, fibro-osseous tunnels, soft tissue tunnels)
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Compression injuries result in what
increased intraneural pressure, decreased blood flow, and increased neural ischemia
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What is carpal tunnel syndrome
compression of the median nerve between the carpal ligament and other tunnel tissues
47
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Carpal tunnel syndrome results in
pain, burning, paresthesia- digits 1-3 and forearm
weakness/atrophy of thenar eminence
48
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Radial nerve mononeuropathy results in
transient paresthesia, numbness, wrist drop (C6), decreased finger extension
49
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Nerve injuries are generally characterized by
demyelination or axonal loss
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What is a crush injury
acute traumatic nerve compression from a blunt object that does not result in nerve transection
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What is a stretch injury
significant traction placed on the nerve usually during higher velocity trauma
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What are transection injuries
lacerations due to fractures or knife, gunshot, or shard wounds
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What are the two classifications of nerve injuries
Seddon
Sunderland
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What is neuropraxia
focal demyelination without damage to the axon or connective tissue
mild nerve compression/traction, compression of blood vessels
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Neuropraxia is characterized by
transient weakness/paresthesia
complete recovery expected
56
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What is axonotmesis
demyelination and axon damage due to stretch, crush, or contusion injury
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Wallerian Degeneration occurs with axonotmesis both proximal and distal to at least
1-2 nodes of ranvier
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Axonotmesis is characterized by
motor, sensory, or automatic dysfunction
connective tissue intact
regeneration may occur at 1mm/day
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What is neurotmesis
complete transection of a peripheral nerve due to trauma resulting in sensory and motor deficits
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Schwann cells and endoneurial tubes can remain viable for how long post injury
18-24 months- surgery needed regrowth occurs at 1mm/day
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What are the positive prognostic factors for neurotmesis
young age, distal nerve injury, end to end repair, early repair
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UMN testing for neurovascular entrapment will show what
hyperreflexia, hyporeflexia, spasticity, hypotonia
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Functional recovery post peripheral nerve injury is often suboptimal as patients with peripheral nerve injuries experience.
increased risk of long term disability
decreased functional capacity
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Why is electrical stimulation not appropriate for denervated muscle
could further damage sensation
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Why does axon regeneration not occur in the CNS
limited by inhibitory influences of glial cells- glial scar
debris not cleared away quickly
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Why is repair limited in the CNS
no schwann cells
astrocytes
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Only the \_____ can repair itself (nerve part)
axon
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How fast does a peripheral nerve grow
1mm/day
69
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Neurons have a resting potential that varies between
-40mV and -90mV
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A stronger stimulus gives rise to more APs but what is always the same
amplitude
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What occurs during an action potential
stimulus applied, Na goes in changing membrane potential, Na channels close, K channels open (repolarization)
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Neurotransmitters can do what two things
excite
inhibit
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What is the synapse processing
AP, Ca channels open, ACh released diffuse across synaptic cleft binds to postsynaptic membrane
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What is temporal summation
several impulses from one neuron over time
single neuron generates AP- less efficient
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What is spatial summation
sensory summation involving adding stimulus from various spatially separated neurons
multiple neurons generate AP
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What is EPSP
excitatory post synaptic potential- exciting environment, easy to fire AP
Na channels open
glutamate
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What is IPSP
inhibitory post synaptic potential- low potential of firing AP
chloride channels open
GABA
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Where do you measure post-synaptic potentials
axon hillock
79
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Acetylcholine is excitatory, it helps with
muscle contraction, cortical neuroplasticity, hormone secretion, short term memory, learning
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Epinephrine/norepinephrine are excitatory, they help with
fight/flight: blood vessel constriction, increased HR, attentiveness, emotions, sleeping
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Dopamine is excitatory and inhibitory, it helps with
movement and posture control, mood, cognition, working memory, reward/reinforcement
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Serotonin is excitatory and inhibitory, it helps with
body temperature, sleep, mood, appetite, pain
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Neurons that use ACh as a transmitter are called
cholinergic neurons- arousal, sleep wake cycle, learning and memory
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Widespread loss of cholinergic neurons is associated with
Alzheimer's disease
85
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ACh is located in the post synaptic membrane of what
neuromuscular junction of straited muscles
visceral motor system
86
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glutamate is an excitatory neurotransmitter that effects what
learning and memory
Site of action- brain
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Glycine is an inhibitory neurotransmitter in
spinal cord
low amounts lead to increased spasticity
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GABA is an inhibitory neurotransmitter that effects what
sedation, antianxiety, antiseizure, sleep induction
low amounts lead to seizures, spasticity, anxiety
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Where is GABA site of action
entire CNS
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Where is dopamine located in the brain
substantia nigra
91
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Many drugs that affect dopamine synapses also affect what
noradrenergic synapses (norepi/epi)
92
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preganglionic sympathetic neurons are called what
cholinergic- use ACh to facilitate nerve transmission
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Postganglionic sympathetic neurons are called what
andrenergic- secrete norepi as their neurotransmitter
94
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pre and postganglionic neurons are called
cholinergic- secrete ACh as their neurotransmitter
95
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The nervous system develops from part of the ectoderm called the
neural plate
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The neural plate forms the
neural tube- walls\= CNS, cavity\=ventricular system
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What produces the CSF
choroid plexus- ependymal cells
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There are two ends of the neural tube (neuropores) that need to close at precisely the right time to prevent what
anencephaly
spina bifida
99
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What is myelomeningocele
cord and nerves develop outside of the body- spina bifida
100
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What is meningocele
meninges and CSF outside the body, doesn't affect neuro- spina bifida
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