TOPIC QUIZ: Dispensing & Adverse Drug Reactions

A medication order written by a medical practitioner to be given to a pharmacist for preparation and dispensing.

Prescription

It is the part of a prescription that contains directions for the patient on how to take the drug:

Transcription

What is written in the Superscription?

Rx

A "STAT" order means that the drug should be administered:

Immediately

Interpret the following instructions: 2 Amoxicillin 500 mg. cap STAT then 1 cap q8h x 7d

Take two 500 mg capsules of Amoxicillin immediately, then take one capsule every eight hours for seven days

The following are manifestations of chemical incompatibility, EXCEPT:

Immiscibility

Precipitation of acacia mucilage upon adding salts is an example of what phenomenon?

Salting-Out

It is considered as the most common type of incompatibility among drugs:

Hydrolysis

A formulation of ferrous sulfate suspension cannot use acacia as a suspending agent, because the final product may exhibit:

Gelatinization

It refers to the decomposition of a substance upon exposure to light:

Photolysis

Which of the following statements regarding drug interaction are TRUE?

I. Drug interaction may result in different responses from the patient to what the drug is primarily intended.

II. Drug interaction may be beneficial

III. Drug interaction may be intentional.

I, II, III

Which of the following is/are valid therapeutic use(s) of a drug interaction?

I. Giving aspirin with warfarin to enhance anticoagulation.

II. Giving multiple antihypertensive drugs to control hypertension.

III. Taking levofloxacin with antacid to decrease GI intolerance of oral therapy.

II

In drug interaction references, "drug affected by the interaction" is referred to as the:

Object

These are therapeutic interactions that occur when one drug alters the absorption, distribution, metabolism, and excretion of the other drug:

Pharmacokinetic

Which of the following drugs can INCREASE the clearance of another drug?

I. Grapefruit juice

II. Phenytoin

III. Smoking

IV. Carbamazepine

II, III, IV

In a drug interaction scenario, what would BEST describe the result if Drug A induces the metabolism of Drug B?

Decrease in the blood concentration of Drug B

If a patient takes Griseofulvin with high fat meal, this will most likely result to

Increase in the absorption of griseofulvin

Alteration of pH can alter the renal elimination of certain toxins. Which of the following may be safely eliminated by alkalinization of the urine?

I. Amphetamines

II. Salicylates

III. Barbiturates

II, III

A mathematical model for a potentiating drug effect

0+1=2

Monoamine oxidase inhibitors combined with tyramine rich food will lead to:

I. Accumulation of pressor amines

II. Increase in blood pressure

III. Non-metabolism of tyramine

I, II, III

The immunoglobulin primarily involved in anaphylactic & hypersensitivity reactions

IgE

Rhus toxicodendron contains a substance that is a mixture of closely related C1S and C17 catechols. This substance causes contact dermatitis. This falls under what type of allergic drug reaction?

Delayed Hypersensitivity

SLE involves a hypersensitivity reaction which may be classified as:

Type III

This is a phenomenon wherein the response to a substance is decreased with continuous use of the same dose of that substance:

Tolerance

A patient with adrenocortical insufficiency is under hydrocortisone therapy. After months of therapy, his facial characteristics changed, and developed a buffalo hump. Which type of drug reaction accounts for these symptoms?

Type C

Teratogenicity is under what type of ADR?

Type D

A pregnancy risk category that indicates that animal studies have shown an adverse effect on the fetus, but there are adequate studies in humans

Category C

Which of the following can induce renal dysgenesis in a fetus?

Lisinopril

Failure to administer an ordered dose before the next scheduled dose may be classified as:

Omission

The error observed in a patient who overdosed on a medication is under what category?

Category B