Antidepressant Drug dosing and other considerations
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22 Terms
citalopram dosing range
20-40mg/day
escitalopram dosing range
10-20mg/day
fluoxetine dosing range
10-80mg/day
paroxetine dosing range
20-50mg/day
sertraline dosing range
50-200mg/day
wellbutrin dosing range
150mg BID-TID
wellbutrin SR dosing range
150-200mg BID
wellbutrin XL dosing range
300-450mg QD
desvenlafaxine dosing range
50-400mg/day
duloxetine dosing range
60-120mg/day
levomilnacipran dosing range
40-120mg/day
venlafaxine dosing range
75-375mg/day
dosing range for mirtazapine
15-45mg/day
dosing range for vilazodone
20-40mg/day
dosing range for vortioxetine
10-20mg/day
when should up titration occur for antidepressants
1-2 weeks based on response and dose range
dosing for hepatic/renal impairment
use lower initial and max doses (decrease by 50%) based on response and tolerability
withdrawal symptoms
starts within 2-3 days and lasts 1-2 weeks
dysphoria
irritability
anxiety
aggitation
insomnia
nausea
dizziness
flu-like
what agents have a high risk of withdrawal symptoms
paroxetine and venlafaxine → due to long half life
pediatrics special considerations
fluoxetine and escitalopram = FDA approved
sudden death syndrome = desipramine
pregnant patient special considerations
weigh benefits vs risks
usually SSRIs and SNRIs are fine
geriatrics special considerations
more sensitive to anticholinergic and orthostasis; at a greater risk for GI bleed and SIADH
*SSRIs are first line for them and usually have a slower response