Aspirin Toxicity in Veterinary Medicine

Vocabulary flashcards covering the symptoms, diagnostics, treatments, and clinical pearls of aspirin toxicity.

Salicylic acid

The major active metabolite of aspirin that inhibits platelet function for the life of the exposed platelets.

Low-dose Aspirin Toxicity

Exposure causing GI ulcers and signs of GI upset typically within $1-4\,d$.

High-dose Aspirin Toxicity (Acute)

Exposure resulting in metabolic acidosis, hyperthermia, seizures, and coma within a few $h$.

High-dose Aspirin Toxicity (Delayed)

Exposure leading to hepatic dysfunction within $1-3\,d$.

Hematochezia and Melena

Clinical signs of ongoing bleeding at any aspirin dose resulting from the inhibition of platelet function.

Buccal mucosal bleeding time

A lab measurement that increases in aspirin toxicity, indicating platelet dysfunction despite a normal platelet count.

Aspirin CNS Effects Mechanism

Neurological signs resulting from low brain glucose levels despite normal peripheral glucose levels.

GI Protectants

Therapeutic agents such as misoprostol, sucralfate, and antacids used to treat aspirin-induced GI ulcers.

IV dextrose CRI

A treatment indicated for aspirin toxicity when neurological signs are present, addressing low cerebral glucose.

Aspirin vs. Other NSAIDs

A clinical distinction where kidney damage is rare in aspirin toxicity compared to other nonsteroidal anti-inflammatory drugs.

Poor Prognosis Indicator

The clinical outcome is generally poor if neurological (CNS) signs are present following aspirin exposure.