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Sexual Differentiation
Chromosomal sex - set at fertilisation
Genetic sex - presence of SRY gene on he Y chromosome
Gonadal sex - type of gonad: presence of the SRY gene
Anatomical sex - internal and external genitalia: exposure to testicular hormone.
Anatomical sex: Paramesonephric ducts
Precursor of uterine tube, uterus and upper part of vagina
AMH secretion by the testes causes regression of these ducts.
No stimulation by T or AMH = continues to develop.
Anatomical sex: Mesonephric ducts
precursor of epididymis, vas deferents, seminal vesicles, ejaculatory ducts
Testosterone stimulates the development of these ducts.
Anatomical sex: External genitalia (penis + scrotum)
At 4-6 weeks genital tissue is bipotential
development requires exposure to testosterone and its local conversion to dihydrotestosterone by 5-alphas reductase.
Genital tubercule:
glans penis
Urethral fold
urethra (fusion of folds)
Labioscrotal
Anatomical sex: External genitalia (clitoris + labia)
No exposure to testosterone or DHT
Genital tubercule develops into:
clitoris
Urethral folds:
labia minora
Labioscrotal swelling:
labia majora
Androgens
family of steroid hormones derived from cholesterol via enzymatic conversion
Defined as a substance capable off of developing and maintaining masculine characteristics
Produced by testes, adrenal glands, and thecal cells of ovarian follicle