Influenza Vaccines and Pathology Lecture

These flashcards cover key concepts about influenza vaccines, antiviral drugs, and the historical context of the influenza pandemic as discussed in the lecture.

What are the two types of influenza vaccines discussed in the lecture?

Trivalent and Quadrivalent vaccines.

What type of vaccine is FluMist?

Live Attenuated influenza vaccine delivered via nasal spray.

How is Flublok produced?

Flublok is made by expressing HA CDNA in insect cells infected with a baculovirus containing the HA gene.

What age group is FluMist recommended for?

FluMist is recommended for healthy individuals aged 2-49 years.

What are the major antiviral drugs for influenza?

Rapivab (peramivir), Relenza (zanamivir), and Tamiflu (oseltamivir).

What is the mechanism of action of Tamiflu (oseltamivir)?

Tamiflu acts as an inhibitor of neuraminidase, preventing virus release.

What are the historical waves of the 1918 influenza pandemic?

The pandemic had three waves: the first was less deadly, the second was extremely virulent, and the third was less virulent.

What symptom pattern is associated with severe influenza infection?

Abrupt illness leading to lower respiratory disease and secondary bacterial pneumonia.

What is the typical mortality rate for seasonal influenza?

It varies, but high-risk groups such as the elderly often face higher fatality rates.

What does the term 'cap snatching' refer to in influenza virus replication?

Cap snatching is the process where the virus takes the 5' cap off host mRNA to replicate its own RNAs.