Components of the Immune System & Lymphoid Organs

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5 Terms

1
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What are the primary (central) lymphoid organs?

Thymus & bone marrow, where lymphocytes originate and mature.

2
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What are the secondary (peripheral) lymphoid organs?

Spleen,

lymph nodes,

tonsils,

appendix,

and mucosal lymphoid tissue of intestine/respiratory tract.

3
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What cells develop in bone marrow?

NK cells,

mononuclear phagocytes,

granulocytes,

and B-cell precursors.

Bone marrow does not contain T cells.

4
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What are the key functions of the thymus?

Provides hormones (thymosins, thymopoietins).

Site of T-cell maturation.

Performs positive & negative selection.

Only ~5% of T cells leave the thymus as fully “educated.”

5
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What zones exist in lymph nodes and what cells dominate them?

  • Cortex → B cells

  • Paracortex → T cells (T-dependent area)

  • Medulla → B & T cells
    They synthesize antibodies when stimulated by particulate antigens.