Alpha-Adrenergic Antagonists

Vocabulary flashcards reviewing alpha-adrenergic antagonists based on provided lecture visual summaries.

Alpha-Adrenergic Antagonists Classification Tree

A visual breakdown dividing alpha-adrenergic antagonists into nonselective (̑\alpha_1 + \alpha_2) agents and selective ($\alpha_1$ or $\alpha_2$) agents, along with their specific subtypes and clinical indications.

Alpha Blockers Summary Chart

A detailed reference chart comparing postsynaptic $\alpha_1$ blockers and presynaptic $\alpha_2$ blockers, including brand names, anatomical sites of action, clinical indications, and adverse effects.

Phenoxybenzamine

An irreversible (covalent) nonselective $\alpha_1$ and $\alpha_2$ adrenergic antagonist used in the management of pheochromocytoma.

Phentolamine

A competitive (reversible) nonselective $\alpha_1$ and $\alpha_2$ adrenergic antagonist used to treat hypertensive crisis and extravasations.

Prazosin (Minipress®)

A selective $\alpha_1$-adrenergic blocker used clinically for hypertension, benign prostatic hyperplasia (BPH), and off-label for PTSD nightmares.

Terazosin (Hytrin®)

A selective $\alpha_1$-adrenergic blocker indicated for hypertension and benign prostatic hyperplasia (BPH).

Doxazosin (Cardura®)

A selective $\alpha_1$-adrenergic blocker indicated for hypertension and benign prostatic hyperplasia (BPH).

Tamsulosin (Flomax®)

A uroselective $\alpha_{1A}$-adrenergic blocker used in the treatment of benign prostatic hyperplasia (BPH).

Silodosin (Rapaflo®)

A uroselective $\alpha_{1A}$-adrenergic blocker used in the treatment of benign prostatic hyperplasia (BPH).

Alfuzosin (Uroxatral®)

A selective $\alpha_1$-adrenergic blocker used to treat benign prostatic hyperplasia (BPH).

Yohimbine (Yocon®)

A selective $\alpha_2$-adrenergic blocker used off-label or investigationally for erectile dysfunction (ED), weight loss, athletic performance, and depression.

Mirtazapine

A selective $\alpha_2$-adrenergic antagonist used clinically in erectile dysfunction (ED) and depression.

Idazoxan (Atipamezole®)

A selective $\alpha_2$-adrenergic antagonist used for the reversal of $\alpha_2$ agonist-induced sedation.

$\alpha_1$ Blockers

Antagonists that block postsynaptic $\alpha_1$ receptors, inhibiting vasoconstriction and smooth muscle contraction in blood vessels, prostate, bladder neck, and the iris radial (dilator) muscle.

$\alpha_2$ Blockers

Antagonists that block presynaptic $\alpha_2$ autoreceptors, leading to increased norepinephrine release from nerve terminals and increased sympathetic tone.

Nonselective Alpha Antagonists

Agents that block both $\alpha_1$ and $\alpha_2$ receptors; their clinical utility is limited by reflex tachycardia.

First-dose Hypotension

A major adverse effect of $\alpha_1$ blockers requiring a explicit "first dose" warning label.