TV4101 - SAM - Erythrocytes

Erythrocytosis: defined as?

increase in [RBC] in peripheral blood identified by increased [RBC], increased HCT or increased [Hgb]

Haemoconcentration?

increased concentration of blood components (incl. RBC) because of decreased plasma volume

Erythrocytosis

Physiological causes?

How does it occur?

Splenic contaction

Erythrocytosis

What is increased?

Increased [RBC], [Hgb], HCT

Erythrocytosis

Haemoconcentration causes?

• Dehydration

• Endotoxic shock

Erythrocytosis - Increased total erythrocyte mass

Two broad groups that fit within this, what are they?

Primary erythrocytosis

Secondary erythrocytosis

Erythrocytosis - Increased total erythrocyte mass → Primary erythrocytosis

Causes include?

• Erythroid neoplasia

• Polycythaemia vera

Erythrocytosis - Increased total erythrocyte mass → Secondary Eryhtrocytosis
Can be broken down into?
Give examples?

Secondary appropriate

erythrocytosis (hypoxia erythrocytosis)

• Cardiac failure

• Respiratory disease

• Hyperthyroidism

Secondary inappropriate erythrocytosis

• Renal neoplasia

• Non-renal neoplasia

Potential Clinical Impacts of Erythrocytosis

If extreme?

Related CX?

Can lead to sludging of blood → impaired blood flow & poor tissue oxygenation
Purplish MM, congested retinal blood vessels and seizures