Abnormal Imprinting Diseases
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What are the two diseases caused by deletion of the long arm of the 15th Chromosome?
Prader-Willi Syndrome and Angelman Syndrome
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Prader-Willi Syndrome
Occurs when deletion is inherited from the father.
Manifests as: Short stature, hypotonia, small hands and feet, obesity, mentally challenged
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Angelman Syndrome
Occurs when deletion is inherited from the mother.
Manifests as: Severely mentally challenged, seizures, ataxic gait
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Note 
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