Lecture 4: Neural Injury and Repair

4 ways that nerves respond to damage

reorganization, regeneration, survival, neurogenesis

what happens to the muscles that are innervated by a damaged nerve

neurogenic atrophy

role of macrophages in nerve regeneration

digest broken pieces of nerve

how do schwann cells help a nerve regenerate

produce factors that guide axon and promote growth to close the gap

T or F: new neurons in the CNS can be made by microglia

false

why is it important to place cut ends of a nerve near each other when repairing

so the factors produced by schwann cells can work

when a neuron gets damaged in the CNS, what glial cells remove debris and how long does it take

microglia, a month

T or F: Repairing neurons in CNS are aided by growth stimulating factors released by Schwann cells

false

can stem cells aid in repair of damaged neurons

yes

is neurogenesis a common mechanism in the brain

no

how does role of glial cells differ in CNS and PNS repair

CNS: produces inhibitory factors, PNS: produces growth factors

why is repair of neurons in CNS less successful that PNS

PNS neurons can regenerate

how does brain recover after a stroke

reorganization