6 - Expectation, Sensitization, Tolerance
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7 Terms
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Tolerance
A decrease in drug effect with repeated administration or an increase in the dose required to produce a similar effect.
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Types of tolerance
acute, pharamcokinetic, pharmacodynamic, functional disturbance, behavioural
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Pharmacokinetic tolerance
occurs when the body becomes more efficient at metabolizing a drug
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Acute tolerance
develops rapidly, often within a single drug administration
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Pharmacodynamic tolerance
involves changes at the site of drug action, changes in receptor sensibility: upregulation, downregulation
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Functional disturbance tolerance
changes in physiological functions that counter the drug’s effect
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Behavioural tolerance
based on drug discrimination learning
Note 
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