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Emergent Properties
result from the arrangement and interactions of parts within a system
characterize non-biological entities within a system
Reductionism
the reduction of complex systems to simpler components that are more manageable to study
Biology balances reductionism with the study of emergent properties
Ex: studying the interactions of DNA with other molecules
System Biology
Constricts models for the dynamic behavior of whole biological systems
Eukaryotic cell
has membrane-enclosed organelles, the largest of which is usually the nucleus
Prokaryotic cell
simpler and usually smaller, and does not contain a nucleus or other membrane-enclosed organelles
Feedback mechanisms
allow biological processes to self-regulate
negative feedback
as more of a product accumulates, the process that creates it slows and less of the product is produced
positive feedback
as more of a product accumulates, the process it creates speeds up and more of the product is produced
three-domain system
plantae, animalia, fungi
Microtubule structure of a cilium
9+2 doublet
(cilia lines the inside of the windpipe)
Elements
substance that cannot be broken down to other substances by clean reactions
Compound
two or more elements
number of elements essential to life
25 out of 92 elements
(carbon, hydrogen, oxygen, nitrogen are most important out of this number)
radioactive isotopes
decay spontaneously, giving off particles and energy
chemically inert
describes elements with a full valence shell
hydrogen bonds
forms when a hydrogen atom covalently bonded to one electronegative atom is also attracted to another electronegative atom
electronegative partners
usually oxygen or nitrogen
(relating to electronegativity)
‘Hot Spots’
positive/negative charges resulting from asymmetrically distributed electrons in molecules or atoms
Van der Waals interactions
happen between molecules that are close together as a result of these charges
(can be strong, as between molecules of a gecko’s toe hairs and a wall surface)
polarity of water
opposite ends have opposite charges
(allows water molecules to form hydrogen bonds with other molecules)
four properties of water
cohesive behavior
ability to moderate temperature
expansion upon freezing
versatility as a solvent
cohesion
hydrogen bonds hold water molecules together
(helps the transport of water against gravity in plants)
adhesion
attraction between different substances
zylum vessels
another name for water conducting cells
functional groups
the components of organic molecules that are most commonly involved in chemical reactions
(the number and arrangement give each molecule its unique properties)
seven functional groups
hydroxyl group: OH or -HO
carbonyl group: C=O or CO
amino group: H2N or NH2
sulfhydryl group: S-H or SH
phosphate group: PO4
methyl group: CH3
carboxyl group: CO2H or COOH
ATP (adenosine triphosphate)
phosphate molecule which is the primary energy-transferring molecule in the cell
Isomers
have the same molecular formula, but different structural formula and different properties
structural isomers
different covalent arrangements
geometric isomers
same covalent arrangements that differ in spatial arrangements
enantiomers
mirror images of each other
(important in the pharmaceutical industry)
Four classes of macromolecules
carbohydrates, lipids, proteins, and nucleic acids
macromolecules
large molecules composed of covalently bonded atoms
polymer
long molecule consisting of many similar building blocks (monomers)
(carbs, proteins, nucleic acids)
condensation reaction
occurs when two monomers bond together through the loss of a water molecule
(more specifically known as a dehydration reaction)
enzymes
macromolecules that speed up the dehydration process
hydrolysis
essentially the reverse of a dehydration reaction
(polymers are disassembled to monomers by this process)
Monosaccharides
simple sugars, also the simplest carbs
polysaccharides
carbohydrate macromolecules, polymers composed of many sugar building blocks
Classification of monosaccharides
The location of the carbonyl group (as aldose or ketose)
The number of carbons in the carbon skeleton
Disaccharide
formed when a dehydration reaction forms two monosaccharides
structure and function
determined by its sugar monomers and positions of glycosidic linkages
starch
Plant saccharide
glycogen
animal saccharide
polysaccharide cellulose
major component of the tough wall of plant cells
alpha and beta
ring forms for glucose
distinguishes starch from cellulose, which are both polymers of glucose
Lipids
include fats, oils, and waxes
Six Classes
Fatty Acids
Eicosanoids
Glycerides
Steroids
Phospholipids
Glycolipids
Triglycerides
three fatty acids affected by dehydration synthesis to one molecule of glycerol
steroids
involved in cell membrane structure
include s-x hormones and hormones regulating metabolism
are important in lipid digestion
Six important functions of proteins
Structural proteins
Contractile proteins
Transport proteins
Enzymes
Buffering proteins
Antibodies
Amino acids
contain an amino group, a carboxylic group, and a radical group
polypeptides
linear segments of amino acids held together by peptide bonds
four levels of protein structure
primary structure (amino acid sequence)
secondary structure (amino acid interactions)
tertiary structure (complex folding)
quarternary structure (protein complexes)
Reactants
interact to yield a product by binding to the active site of the enzyme
(aka substrate)
cofactors
must bind to the enzyme before substrate binding can occur
Make up of nucleotide
made up of phosphate, pentose sugar, nitrogenous base
nucleoside
portion without phosphate group
pyrimidines
thymines, uracil, and cytosine
six-membered ring
purines
adenosine and guanine
six-membered ring fused to a five-membered ring
a purine
a ____ will always base pair with a pyrimidine molecule
adjacent molecules
joined by covalent bonds that form between the -OH group on the 3’ carbon of one nucleotide and the phosphate on the 5’ carbon on the next
(these links create a backbone of sugar-phosphate units with nitrogenous bases as appendages)
Polynucleotide
a hydrogen bond is a ______