MHC and COMPLEMENTs

• All nucleated cells

  • RBC has NO MHC

Major Histocompatibility Complex can be found in _______, except _______

• Human Leukocyte Antigen (HLA)

Previous name of MHC

• Carries brokendown peptide antigen to be presented to Lymphocytes (T-Cells)

• Determine tissue compatibility during organ transplant

Major Function of MHC

• 6p21.3 (Short Arm of Chrosome 6, Region 2, Band 1, Sub-band 3)

Where can we found the gene coding for MHC

• A, B, C

In what LOCUS is Class 1 coded

• DR, DQ, DP

In what LOCUS is Class 2 coded

• Endogenous

• CD8+ cytotoxic T Cells

MHC Class 1 presents _______ antigen to ______ T cell

• Exogenous

• CD4+ Helper T cells

MHC Class 2 presents _______ antigen to ______ T cell

Class 3

This MHC class encode for immune-related proteins (complement)

• MHC 1 = all nucleated cells

• MHC 2 = Antigen-presenting cells

• MHC 1 is found in ______ cells

• MHC 2 is found in ______ cells