MUTATIONS -- mutagens

mod 1

what is a mutagen?

an agent capable of increasing the frequency of mutation

example of an alkylating agent (mutagen)

EMS

what does EMS do to cause a mutation?

adds alkyl groups to DNA bases

what effect does an alkylation of a base have on DNA replication?

DNA polymerase incorporates an incorrect base opposite the newly changed one

what mutation does EMS cause?

substitution of GC to AT

what’s an example of a base analogue mutagen?

2-aminopurine