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What kind of cells does HIV destroy?
CD4+ T cells
When can HIV symptoms start and what are some examples of these symptoms?
2-12 weeks
Fever, fatigue, Night sweats, arthralgia, myalgia, headache
What are the 3 ways HIV can be transmitted to another person?
Blood
Sexual contact
Mother to child
What’s the most common lab testing to determine if you have HIV?
Lab CD4+ count
What’s the normal range for CD4+ lab count?
500-1200 cells/mm3
What’s a counterintuitive aspect of ART (Antiretroviral therapy)?
Suppresses immune system to an extent which is needed to prevent organ damage.
What does HIV stand for?
Human Immunodeficiency Virus
What do NRTIs stand for? What do you need to know about them in regards to food with the exception of Didanosine?
nucleoside Reverse transcriptase inhibitors
Can take without regards to food with the exception of Didanosine which needs to be taken 30 minutes before or 2 hours after.
How do NRTIs work?
Mess with HIV RNA
What are NRTIs most notable SEs?
GI disturbances (nausea, diarrhea, pain), peripheral neuropathy, pancreatitis
What do NNRTIs stand for? Basic way they work
Non-nucleoside reverse transcriptase inhibitors
Bind directly to DNA so HIV can’t do much more harm
SEs for NNRTIs:
Stevens-Johnson’s syndrome and hepatotoxicity
Protease inhibitors SEs
Steven-Johnson’s syndrome, MI
Fusion entry inhibitors SEs
Anaphylaxis
CCR5 Antagonists main SE
Upper resp infections
Integrase strand transfer inhibitors (INSTIs) SEs
Rhabdomyolysis (release of proteins into blood from muscles),
What is PEP and what’s its goals? How soon do you need to seek treatment, and how long after exposure should you keep up treatment?
Post-Exposure Prophylaxis: Within 72 hours of exposure for 4 weeks
