Antigen Receptors/MHC

What causes the Ig domain to be stable?

Disulfide bonds

Which antibodies do not have a hinge region?

IgE and IgM

Which CDR uses VDJ recombination?

CDR3

Which MHC has a larger groove without walls?

MHC II

How many MHC molecules can be expressed through genes?

18

What is the function of ERAP?

Chops up peptides to make them shorter

Which MHC has peptides that may bulge outward?

MHC I

Which MHC has peptides that are typically flatter?

MHC II

Which genes are the most polymorphic?

MHC genes

What transports peptide fragments from the cytosol to the ER?

TAP

What is cross presentation?

Presentation of exogenously derived antigen peptides on MHC I

What does CD1 present?

Lipid antigens

What does MR1 present?

Metabolic derivatives to MIATs

What is the function of HLA-E?

Inhibits NK cell activation