Translation initiation

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9 Terms

1
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What structure is essential for initiation?

5′ cap

2
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How does the ribosome find the start codon?

Scanning to first AUG

3
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What amino acid initiates translation?

Methionine

4
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What is the Kozak consensus sequence?

CCACCAUG or CCGCCAUG

5
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Why is mRNA circularised?

Enhances reinitiation and integrity

6
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Which protein binds the cap?

eIF4E

7
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Which protein binds the poly(A) tail?

PABP

8
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Which protein links both ends?

eIF4G

9
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Why do viruses target eIF4G?

To block mRNA circularisation