PC2 MOD 4.1.2 PART 2

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Last updated 4:07 AM on 9/11/26
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7 Terms

1
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type 1 INF mediated antiviral response

no info

2
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Innate immunity

  • CD8+ T cell mediated killing of virus infected host cells

  • NK cell-mediated neutralization

  • complement-mediated naturalization


3
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adaptive immunity

TLR mediated recognition of viral DNA/RNA by APCs leads to antibody production

4
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TYPE 1 INF during viral infection

  1. low lvls of type 1 INF (INFa & B)

  2. more INFs produced in response to viral infection/contact w/viral

  3. INFs get feedback and prompt transcription of ISGs

  4. ISGs block viral replication cycle


5
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how do TYPE 1 INFs recognize pathogens

  • TLR

  • RNA PRRs: RIG 1, MDA5, NOD 1 & 2

  • DNA PRRs: DAI, cGAS


6
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INFa/B production & effects

viral recognition by PRRs→ activation of INF transcription factors (IRF3/IRF7, Alt-IRF, NF-kB, AP-1)→ INFa/B gene transcription & translation→ INFa/B binding IFN receptor on target cell→ production of ISGs→ ISGs interfere w/viral entry, replication, assembly, & exit


7
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type 1 INFs promote antiviral responses

  • promote CD8+ T cell proliferation

  • increase MHC-1 expression on APCs

  • enhance NK cell killing of virus infected cells