Calcitonin

Identify the factors influencing calcitonin secretion, and the potential therapeutic applications of calcitonin

Where is calcitonin produces

In parafollicular cells (C-cells)

What is the function of calcitonin

reduce Ca2+ levels

-released when Ca2+ > 9

What stimulates Calcitonin release

High Ca2+ levels

dopamine

GASTRIN: Released after a meal to modulate calcium from dietary sources

beta-adrenergic agonists (mimic)

Zollinger-Ellison Syndrome

condition caused by tumors = gastrinomas = that secrete excess gastrin

HIGH GASTRIN = HIGH/elevated CALCITONIN LEVELS

How is calcitonin used for therapy

GPCR

Reduces Ca2+

Reduces bone resorption + renal Ca2+ reabsorption = offers therapeutic application!

What is the effect of low calcium on muscles

Tetanus/spasms!

low calcium = ion channels are MORE sensitive = easily excitable

Signs of hypocalcemia (LOW)

-Is QT long or short?

• Confusion

• Weakness

• Chvostek + Trousseau signs

• Muscle cramping 

• Prolonged QT interval (Calcium channels are open longer)

signs of HYPER parathyroidism

long or short QT

Bone pain- too much caclium released (high PTH= high bone resoprtion/break down)

poor concentration

Renal stones

Constipation

short QT