(RMT) Chem - Quality Control

pareh

range

difference between highest and lowest value

range

easiest measure of spread

standard deviation (SD)

most frequently used measure of variation

coefficient of variation

index of precision

coefficient of variation

to compare dispersion of two or more groups of data with different unites/concentrations.

t-test

means of 2 groups of data

f-test

SD of 2 groups of data

bell curve

symmetrical shape

accuracy

nearness/closeness to true value

precision

nearness/closeness to each other

degree by which which method can easily be repeated

reportable range

aka Linearity

reference interval

formerly called Normal Value

establishing a reference interval

new reference interval - 120 to 700 study individuals

transference and validation of a reference interval

most common reference interval - 40 study individuals

true positive

positive result - has dse

false positive

positive result - no dse

true negative

negative result - no dse

false negative

negative result - has dse

5 and 20 days

control materials should be analyzed between which days?

general chemistry assays

2 levels of control solutions

immunoassays

3 levels of control solutions

1 year

QC materials should last how long?

aliquoted in stable form (lyophilized)

typical form of QC materials

BIORAD

most common manufacturer

lewey-jennings control chart

aka Shewhart plot

lewey-jennings control chart

most common presentation for evaluating QC results

trend

main cause: systematic error

shift

main cause: random error

outlier

highly deviating values control result is outside established limits

1 2s

warning rule

1 3s

random

R4s

random

2 2s

systematic

4 1s

systematic

3 1s

systematic

10x

systematic

systematic

across run

1 control

within run

2 control

random error

due to chance

systematic error

error that influences all observations consistently in one direction

SACCL

hiv sample

RITM

hiv donor blood

lean six sigma

for quality improvement

lean six sigma

problem-cause-solution methodology

NRL

proficiency testing conducted

proficiency testing

aka EQAS