Biophysics - Week 1 Lecture 3

Free entropy and microstates

S = k ln (w)

S = entropy

k = Boltzman constant

w = microstates

k = ?

1.38 × 10^-23 m²kgs^-2K^-1

microstates

The specific way in which the energy of a system is arranged. Indistinguishable. More indistinguishable = higher entropy

w = ?

w = (N!/Np!(N-Np)!

N= total possible sites

Np = sites chosen

def of Free energy (F= G)

A measure of energy that is available to do work

F = G = E - T S

[E = mechanical energy (enthalpy) , T = temp , S= entropy ]

When you lower the energy, what happened to the chemical bonds?

stronger/more chemical bonds

what happens when system is not at equilibrium

entropy will increase until it reaches max value = free energy minimized

Gibbs free energy (F=G)

ΔG = ΔH = TΔS

(-) (-). (+) spontaneous [exergonic]

(+) (+) (-) [endergonic]

(+/-) (+) (+) with high T = spontaneous

(+/-) (-). (-) with low T