Blood Bank I Blood Group Antigens

ABO rxn temp

cold

ABO complement fixation

yes

ABO clinical significance

HDN, HTR

ABO special feature

reverse type, subgroups

ABO chr

9

Rh rxn temp

warm

Rh complement fixation

no

Rh enzyme affect

enhanced

Rh clinical significance

HDN, HTR

Rh special features

Rhogam, haplotypes

Rh chr

1

Kell antigens

K/k, Kpa/Kpb, Jsa/Jsb

Kell rxn temp

warm

Kell complement fixation

no

Kell enzyme affect

DTT, destroyed

Kell clinical significance

HDN

Kell chr

7

Lewis rxn temp

cold

Kell high frequency antigens

k, Kpb, Jsb

Lewis complement fixation

no

Lewis enzyme affect

enhanced

Lewis clinical significance

no

Lewis special feature

secretor

Lewis chr

19

Kidd antigens

Jka/Jkb

Kidd complement fixation

yes

Kidd enzyme affect

enhanced

Kidd clinical significance

delayed HTR (extravascular hemolysis), HDN

Kidd special feature

hide and seek titer, 2M urea lysis

Kidd chr

18

Duffy antigens

Fya/Fyb

Duffy rxn temp

warm

Duffy complement fixation

variable

Duffy clinical significance

HDN, HTR, not as severe

Duffy special feature

resistance to P. vivax

Duffy chr

1

MNS antigens

M/N S/s

MNS rxn temp

cold (M/N) warm (S/s)

MNS complement fixation

variable

MNS enzyme affect

reduced

MNS clinical significance

S/s: HDN, HTR M/N: some

MNS special feature

neg. charge, slight P. falciparum resistance

P antigens

P1, P, PK

P rxn temp

cold

P complement fixation

yes and no

P clinical significance

some, anti-PP1Pk = spontaneous abortion

P special feature

pigeon egg and hydatid cyst fluid neutralizes

P chr

3

MNS chr

4

Lutheran antigens

Lua/Lub

Lutheran high frequency antigens

Lub

Lutheran rxn temp

Lua: cold, Lub: warm

Lutheran complement fixation

variable

Lutheran enzyme affect

resistant, destroyed by DTT

Lutheran clinical significance

cancer research, sickle cell disease

Lutheran special feature

mixed field ab due to variable expression

Lutheran chr

19