Failure of negative selection and peripheral tolerance of B cells (cont’d)
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4 Terms
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What happens to anergic B cells in the body?
They are not activated and are quickly removed due to their short half-life.
2
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Which signaling molecules drive B-cell anergy?
SHIP-1 and SHP-1 drive the activation of anergy in B cells.
3
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What is Bim’s role in removing anergic B cells?
Bim promotes apoptosis of anergic B cells that don't receive survival signals.
4
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What happens if SHIP-1, SHP-1, or Bim is lost?
Loss of these prevents anergy, allowing self-reactive B cells to enter circulation.
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