Endometrial carcinoma

Endometrial carcinoma background (2)

1. Most common type of uterine cancer

2. Can progress to Adenocarcinoma

Two types of endometrial carcinoma

1. Endometrioid carcinoma

2. Serous carcinoma of the endometrium

Endometrioid carcinoma Precursor “lesion”

Hyperplasia with atypia

Endometrioid carcinoma age

Younger post-menopausal

Endometrioid carcinoma Unopposed estrogen involvement?

Yes

Endometrioid carcinoma Genetic mutation

PTEN (Tumor suppressor)

Endometrioid carcinoma Tumor characteristics Prognosis

Well differentiated (low grade)

Endometrioid carcinoma Symptoms

Abnormal bleeding

Endometrioid carcinoma Prevalence

80%

Serous carcinoma of the endometrium Precursor “lesion”

Endometrial atrophy

Serous carcinoma of the endometrium age

Older Post-menopausal

Serous carcinoma of the endometrium Unopposed estrogen involvement?

No

It loses estrogen = atrophy

Serous carcinoma of the endometrium Genetic mutation

TP53

Serous carcinoma of the endometrium Tumor characteristics Prognosis

Poorly differentiated (high grade)

Serous carcinoma of the endometrium symptom

Abnormal bleeding

Serous carcinoma of the endometrium previlance

15%

Endometrial polyps (2)

1. Benign mass of endometrial tissue (stromal cells are neoplastic)

2. Very common around menopause