Seizure & Anesthesia Meds

Phenytoin

na channel blocker, clearance sat=therapeutic range, liver enz ind

Fosphenytoin

na channel blocker, no precipitation, IV

Carbamazepine

Na channel blocker, liver enz ind, HLA rash, bone marrow sup

Oxcarbazepine

Na channel blocker, no auto ind

Lamotrigine

Na channel blocker, down glutamate, SJS rash

Valproate

Na channel blocker, T-type Ca channel blocker, Gaba enhancer, liver enz ind

Ethosuximide

T-type ca channel blocker, bone marrow sup

Gabapentin

binds Ca channels, down NT release, renal cleared, sedation

Pregabalin

gabapentin, faster

Levetiracetam

down synaptic protein vesicle, down NT release, renal cleared

Lacosamide

same as levetiracetam, prolong PR int

Phenobarbital

gaba-a enhancer, sedation, liver enz ind

Primidone

metabolized into phenobarbital

Topiramate

carbonic anhydrase inhibitor

Pyridostigmine

blocks Ach metabolism, tx myasthenia gravis

Baclofen

Gaba-b enhancer on spinal cord, down reflex tone

Cyclobenzaprine

similar to tricyclic antidepressants, sedation for spasms

Diazepam

Gaba-a enhancer

benzodiazepine antidote

flumazenil

Propofol

Gaba-a enhancer, hypotension, apnea

Etomidate

anesthesia for weak heart

Ketamine

dissociative anesthesia, some analgesia, increase HR & BP, emergence rxn

Isoflurane

volatile agent inhaled with vaporizer, hypotension, resp dep, malignant hyperthermia

Sorflurane

inhaled anesthesia

Nitrous Oxide

gaseous anesthesia, weak need combo drug

Succinylcholine

depolarizing blocker, fasiculations, increase K, malignant hyperthermia, no reversal

Pancuronium

non depolarizing agent, renal cleared, revered with ACh (atropine)

Rancuronium

short nondepolarizing blocker

Vecuronium

short nondepolarizing agent

Lidocaine

amide local anesthesia

Bupivacaine

amide, local anesthesia, cardio toxic

Chloroprocaine

Esther, local anesthesia, OB

Cocaine

Esther, local anesthesia, constricts vessels