T Cell Receptors (TCRs)

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10 Terms

1
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What is the basic structure of the TCR?

Alpha and beta chains (or gamma and delta)

2
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How many domains does a TCR have?

Four Ig-like domains

3
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Does the TCR bind the free antigen?

No

4
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What does the TCR bind?

Peptide-MHC complexes

5
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Where does TCR recognition occur?

On the surface of other cells

6
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How many CDRs contribute to TCR binidng?

Six

7
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Are TCRs larger or smaller than antibodies?

Smaller

8
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Where are TCR genes rearranged?

In the thymus

9
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Is somatic hypermutation involved in TCR generation?

No

10
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Are TCRs ever secreted?

No