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When genetic sex is determined
At birth
Genetic makeup of sperm
X or Y
Y chromosome
Chromosome that codes for sex
Genetic makeup of Ova
X
SRY gene
Sex determining region on Y chromosome
SRY gene code
Testes determining factor that releases a protein that influences gonadal development
SRY translocation
Testes develop still
Absence of SRY signal
Female gonadal development occurs
Genetic sex
Determines what gonads develop
Presence of SRY gene
Testes develop
Development of internal sex organs
Hormones secreted by gonads determine
Mullerian system
Precursor to the internal female sex organs
Requirement of mullerian system
No additional hormones are needed
Wolffian system
Precursor to male internal sex organs
Requirement of wolffian system
Needs hormones to develop
Genetic composition of Turner syndrome
XO
Effects of Turner Syndrome
Not fully developed ovaries due to missing X, normal internal sex organs, normal external genitalia, cannot bear children
Testes secrete
Anti-mullerian hormones and androgens
Anti mullerian hormones
Inhibit development of female internal organs - defeminizing effect
Androgens
Stimulate development of Wolffian system - Masculinizing effect
Types of androgens
Testosterone and dihydrotestosterone
AIS genetic makeup
XY with dysfunction androgen receptor
Cause of AIS
No androgen receptor inhibits Wolffian development, no development of male external genitalia
Effects of AIS
Mullerian system is suppressed, but female external organs still develop giving a female appearance
Genetic makeup of Mullerian Duct Syndrome
XY disorder
Effects of PMDS
aMH receptors or genes are dysfunctional and female organs interfere with function of male organs
Organizational effects
Effect of hormones prenatally on sex organs and brain development
Primary sex characteristics are
Influenced by Organizational effects
Activational effects
The effect hormones have during puberty
Secondary sex characteristics are
Influenced by activational effects, but depends on organizational effects
Primary sex characteristics
Gonads, internal sex organs, and external genitalia
Testes secrete
Testosterone - Wolffian, anti mullerian hormones, dihydrotestosterone - External
Lack of testes
No androgens are secreted, mullerian system develops and external female genitals develop
Secondary sex characteristics
Emerge at puberty, male: grow bears, axillary hair, voice drop; female:Re-distribution of fat, breasts develop, menstrual cycle begins
Hypothalamus
Secretes Gonadotropin releasing hormones (GnRH)
Anterior pituitary gland
Responds to GnRH by releasing gonadotropic hormones
Gonadotropic hormones
Follicle stimulating hormone (FSH) and Leutenizing hormone (LH)
Gonads
Respond to GH’s by releasing their own hormones
Hormones
Effect their target tissues and organs producing secondary sex characteristics
Effect of testosterone
Production of sperm, facial hair, pubic and axillary hair, voice deepens, and increased sex drive
Effects of estradioal
Maturation of female genitals, breasts, fat deposits, growth of uterine lining
Kisspeptin
Protein produced in Arcuate Nucelus that modulates GnRH release
Function of Kisspeptin
Essential for initiation of puberty and maintenance of male and female reproductive ability
Genetic makeup of Klienfelter’s Syndrome
XXY
Effect of Klienfelter’s syndrome
Testes and male genitals develop but XX combination impedes male development, reduces testes and genitals
Genetic makeup of Jacob’s syndrome
XYY
Mammalian female reproductive cycle
Estrus cycle
Estrus cycle
Hormonal states regulate reproductive behaviors
Primate female reproductive cycle
Menstrual cycle
Menstrual cycle
Hormones regulate fertility, but not mating behaviors, can engage in mating behaviors anytime
Ovarian follicles
Stimulated by the release of FSH, cluster of cells surrounding ovum
Mature ovarian follicles
Secrete estradiol which induces uterine lining growth for implantation of egg
Leutenizing hormone
Induces ovulation after ovarian follicle ruptures releasing ovum to fallopian tube
Corpus luteum
Left behind ovarian follicle cells
Corpus luteum secretes
Estradiol and progesterone
Estradiol
Primary female hormone
Progesterone
Important for maintaining lining of uterus, inhibit release of FSH and LH
Hormonal influence on behaviors
Females are more likely to initiate during ovulatory phase
Male hormonal regulation
LH stimulates testosterone production, FSH maintains sperm production
Low testosterone
Reduced sperm production and interest in sexual behaviors