Drugs Acting on Renal System

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11 Terms

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NSAIDs

M.O.A

They inhibit prostaglandin synthesis by blocking the cyclooxygenase(COX)-1 and COX-2 isoenzymes, which results in the suppression of inflammation and pain

Clinical

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Aminoglycosides:

M.O.A

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Statins

M.O.A

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Proton Pump Inhibitors (PPIs)

M.O.A

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In the kidneys, COX-1?

regulates renal hemodynamic and glomerular filtration rate (GFR)

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COX-2 in kidney function?

affects salt and water excretion

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Antidote for NSaid induced AIN

prednisone

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long-term opioids in CKD May cause

albuminuria

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PPI other use ?

prophylactic in NSAID users to decrease

peptic ulcer risk.

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most common causes of drug-induced AIN (acute intestinal nephritis).

PPIs

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