Exam 2 rando drugs

Vigabatrin:

1. GABA-T inhibitor

   • decreases GABA metabolism

   • increases levels of presynaptic GABA

2. Decreases neuronal fire

used for seizures

Carbamazepine

• Stabilizes sodium channels

• reduces neuronal firing

Used for seizures

Lamotrigine

• Na channel blocking

• reduces neuronal firing

Used for seizures

Tia-gabine

A selective inhibitor of GAT-1 (transporter),

• reduces seizure onset

• Reduces clearance

• Elevates extracellular/synaptic GABA levels

• Enhances GABAergic transmission in several brain areas

Keto-diet & epilepsy

1. net increase of GABA

2. Inactivation of VGLUT

3. Altered levels of other NTs

4. Antioxidant effects

Dantrolene

Drug for malignant hyperthermia

Prazosin

Alpha 1 adrenergic blocker

Teraozin

Alpha 1 adrenergic blocker

Doxazosin

Alpha 1 adrenergic blocker

Propanolol

Beta blocker

Dimecarpol

Drug of choice for certain metal toxicities