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phrenology
studying bumps on the skull; once believed to reveal mental abilities and character traits
localization of function
various brain regions have particular functions
biological psychologists
links between biological activity and psychological events
neurons
nerve cells
dendrite fibers
receive info and conduct it toward the cell body/soma
axon fiber
sends info through terminal branches to other neurons or muscles/glands - long
myelin sheath
layer of fatty tissue that insulates and speeds up impulses; degenerates in multiple sclerosis
multiple sclerosis
degeneration of myelin sheath, slower communication to muscles
neurons transmit messages when
stimulated by sensory signals or chemical signals from neighboring neurons; response coordinated by the nucleus
action potential
a brief electrical charge that travels down the axon and leads to synaptic activity
node of Ranvier
what the action potential "jumps on" between myelin
potential
separation of charge, "potential" to do work
voltage-gated channels
when V approches -55 mV, they open and allow Na+ in; when V approaches +30 mV, they open and allow rush of K+ out
depolarization
Na+ ions move in, increasing V
repolarization
K+ ions move out, decreasing V
graded potential
voltage moving towards and away from threshold, but not reaching it
resting potential
typically -70 mV, fluid inside axon's membrane has more K+, less Na+ and Cl-
leak channels
allow some K+ to move out, charge becomes more positive outside for a greater difference
Na+/K+ pump
keeping up with the leaking, requires ATP
refractory period
neuron pumps the Na+ ions back outside, recharging it back to -70 mV so it can fire again
excitatory signals
those that push the neuron closer to an action potential
inhibitory signals
those that pull the neuron further from an action potential
if excitatory > inhibitory by a minimum intensity (threshold)
combined signals trigger an action potential
all-or-none response
increasing stimulation above the threshold does not affect intensity; the neuron either fires or doesn't
the higher the frequency of action potentials
the stronger the sensation
we differentiate stimulus intensity by
number of neurons fired and frequency
threshold voltage
-55 mV
synaptic cleft
separation between axon terminal of one neuron and receiving neuron
neurotransmitters
chemical messengers that cross the synaptic cleft and bind to receptor sites on the receiving neuron
chemically-gated channels
located on receiving neuron, excited (allow Na+ in) or inhibited (allow K+ out or Cl- in) by neurotransmitter
reuptake
sending neuron reasorbs excess neurotransmitters; can also be destroyed by enzymes
acetylcholine
learning and memory, messenger at every junction between motor neurons and skeletal muscles, paralysis if blocked
dopamine
influences movement, learning, attention, and emotion; oversupply linked to schizophrenia, undersupply linked to termors and decreased mobility in Parkinson's disease
serotonin
affects mood, hunger, sleep, and arousal; undersupply linked to depression
noradrenaline
helps control alertness and arousal; undersupply can depress mood
GABA (gamma-aminobutryic acid)
major inhibitory neurotransmitter; undersupply linked to seizures, tremors, and insomnia
glutamate
major excitatory neurotransmitter involved in memory; oversupply can overstimulate the brain, producing migraines or seizures
opiate receptors
respond to morphine and naturally-produced endorphins
agonist molecules
similar to neurotransmitters and can bind to their receptors to mimic effects
antagonist molecules
block a neurotransmitter's receptor and prevent its effect
nervous system
allows our body to take in info from around the world and its tissues, to make decisions, and to send back info and orders to its tissues
central nervous system
brain and spinal cord; body's decision maker
peripheral nervous system
gathers info and transmits CNS decisions to other body parts
nerves
electrical cable formed of bundles of axons, link CNS with body's sensory receptors, muscles, and glands
sensory neurons
carry messages from body's tissues and sensory receptors inward to brain and spinal cord for processing
motor neurons
carry instructions from CNS to muscles and glands
motor neurons found in
cardiac muscles, skeletal muscles, smooth muscles, and endocrine glands
interneurons
brain's internal communication system, process info between sensory input and motor output
somatic nervous system
within peripheral; enables voluntary control of our skeletal muscles
autonomic nervous system
within peripheral; controls our glands and internal organs’ muscles, usually operates autonomously
sympathetic nervous system
within autonomic; arouses and expends energy (e.g. higher heartbeat and BP, slower digestion, sweating)
parasympathetic nervous system
within autonomic; opposite of sympathetic, conserving energy as it calms you
neural networks
work groups that can have shorter, faster connections, multiple layers and connections to the next layer
learning occurs as
experience strengthens and modifies certain connections in response to feedback
spinal cord
two-way highway connecting the PNS and brain
ascending neural fibers
send sensory info up spinal cord
descending neural fibers
send motor control info back down spinal cord
reflex pathways
composed of a single sensory neuron and a single motor neuron, often communicating through an interneuron—faster response than if info was sent all the way to the brain
endocrine system
has glands that secrete hormones
hormones
chemical messengers that travel through the bloodstream and affect other tissues; can act on the brain; slower and tend to last longer than nerve impulses
adrenal glands
above the kidneys; release adrenaline and noradrenaline which control the fight-or-flight response (increase heart rate, BP, and blood sugar)
pituitary gland
"master gland"; releases growth hormone, oxytocin, triggers sex glands to release sex hormones, triggers adrenal glands to release cortisol
oxytocin
enables birth contractions, milk flow during nursing, orgasm, pair bonding, group cohesion, and social trust
cortisol
released by adrenal glands in a stressful event to increase blood sugar
hypothalamus
brain region that controls the pituitary
thyroid gland
regulates metabolism through thyroxin
parathyroids
helps regulate calcium level in blood
pancreas
insulin and glucagon to regulate blood sugar level
ovary and testis
secrete female and male sex hormones
lesion
using high frequency electrodes to burn away target tissue; similar damage can also be caused by stroke or seizures; provided hyperlocal observations
microelectrodes
can pick up on the messages of individual neurons
electroencephalogram (EEG)
amplified readout of electrical activity waves (i.e. electrical waves caused by a stimulus are kept; other unrelated activity is filtered out)
computed tomography (CT) scan
takes X-ray photos that can reveal brain damage
positron emission tomography (PET) scan
depicts brain activity by showing each brain area's glucose consumption through temporarily radioactive glucose that releases gamma rays
functional MRI
can reveal the brain's functioning as well as structure by comparing MRI scans taken close together to watch blood move into specific brain areas
increasing complexity arises from
new brain systems built on top of the old (e.g. brainstem, thalamus, and cerebellum)
brainstem
oldest and innermost region responsible for automatic survival functions; crossover point for nerves connecting to opposite side of body from brain
medulla
in brainstem; controls heartbeat and breathing
pons
in brainstem; coordinates movements for purposeful tasks
thalamus
pair of egg-shaped structures; sensory control center (except for smell) that receives info and routes it to higher brain regions i.e. cerebral cortex; receives some replies which it directs to medulla and cerebellum
reticular formation
neuron network that extends from the spinal cord up through the thalamus; incoming stimuli from spinal cord is filtered and important info is relayed to other brain areas; also enables arousal, attention, sleep, and awareness to environment
cerebellum
"little brain", enables nonverbal learning and memory, judges time, modulates emotions, discriminates sounds and textures, works with pons to coordinate voluntary movement and balance, one of the first structures to be affected by alcohol
hindbrain region
includes spinal cord, medulla, pons, and cerebellum
midbrain region
roughly below thalamus, integrates different sensory processes, creates dopamine-releasing neurons that project into higher brain areas
hippocampus
processes conscious memories and forms new ones
amygdala
linked to aggression and fear responses, the perception of these emotions, and processing of emotional memories
hypothalamus
controls autonomic nervous system and influences pituitary gland; bodily maintenance through hunger, thirst, and sexual behavior; tunes blood chemistry and incoming orders from other brain parts
4 Fs that the hypothalamus controls
fighting, fleeing, feeding, and fucking
nucleus accumbens
another reward center in front of hypothalamus
limbic system
hippocampus, amygdala, hypothalamus, and nucleus accumbens
forebrain
cerebrum, thalamus, hypothalamus, and pituitary gland
reward deficiency syndrome
occurs in addictive disorders e.g. substance use and binge eating because of malfunctions in natural brain pleasure systems
glial cells
supportive in neuron's function of nervous system communication
astrocytes
glial cell in CNS; support neurons by maintaining chemical concentrations in extracellular space, removes waste, repairs tissue, and contributes to blood-brain barrier by wrapping around capillaries in the vascular foot process
satellite cells
glial cell in PNS; found surrounding sensory and autonomic ganglia to regulate their microenvironment
oligodendrocytes (CNS) and Schwann cells (PNS)
glial cells that insulate axons with myelin sheath
microglial cells
glial cell in CNS; ingest cells and pathogens for immune support
ependymal cells
glial cell in CNS; tightly adherent to each other, filter blood to make cerebrospinal fluid which protects CNS neural structures; found in choroid plexus in brain ventricles
cerebrum
outer covering of gray matter over the hemispheres containing newer neural networks that enable perception, thought, and speech
cerebral cortex
thin surface layer of interconnected neural cells, control and information processing center