Pharmacology Module 2

0.0(0)
learnLearn
examPractice Test
spaced repetitionSpaced Repetition
heart puzzleMatch
flashcardsFlashcards
Card Sorting

1/140

encourage image

There's no tags or description

Looks like no tags are added yet.

Study Analytics
Name
Mastery
Learn
Test
Matching
Spaced

No study sessions yet.

141 Terms

1
New cards

Bactericidal

Antibiotics that Kill bacteria.

2
New cards

Can bactericidal be reversed?

no

3
New cards

How does bactericidal kill bacteria?

Inhibit cell wall formation

4
New cards

Does bactericidal rely on the host immunity?

no

5
New cards

Bacteriostatic

Antibiotics that prevent bacterial growth

6
New cards

Is bacteriostatic reversible?

yes

7
New cards

Does bacteriostatic rely on host immunity?

yes

8
New cards

How does bacteriostatic affect bacteria?

Inhibits DNA replication and protein synthesis

9
New cards

Is penicillin an example of bactericidal or bacteriostatic?

bactericidal

10
New cards

Is cephalosporin an example of bactericidal or bacteriostatic?

bactericidal

11
New cards

Is carbapenem an example of bactericidal or bacteriostatic?

bactericidal

12
New cards

Is monobactam an example of bactericidal or bacteriostatic?

bactericidal

13
New cards

Is vancomycin an example of bactericidal or bacteriostatic?

bactericidal

14
New cards

Is Tetracyclines an example of bactericidal or bacteriostatic?

bacteriostatic

15
New cards

16
New cards

Is clindamycin an example of bactericidal or bacteriostatic?

bacteriostatic

17
New cards

Is fluroquinolones/ metronidazole bactericidal or bacteriostatic

bactericidal

18
New cards

Is sulfonamides/trimethoprim bactericidal or bacteriostatic

bacteriostatic

19
New cards

Is Macrolides an example of bactericidal or bacteriostatic?

bacteriostatic

20
New cards

When is broad spectrum used?

before culture and sensitivity

21
New cards

Broad spectrum targets a

wide range of bacteria

22
New cards

What is the problem with broad spectrum?

It can cause more adverse effects

23
New cards

When is narrow spectrum used?

after culture and sensitivity

24
New cards

Narrow spectrum targets

specific groups of bacteria

25
New cards

What is the benefit of narrow spectrum?

less adverse effects

26
New cards

How can antimicrobial resistance be prevented?

use antibiotics only when prescribed, follow dosing, don’t overuse

27
New cards

When is prophylactic treatment used?

When trying to prevent the client from getting sick

28
New cards

The general adverse effects of antibiotics are

GI disturbance, oral thrush, diarrhea, C.Diff

29
New cards

Define culture

a patient sample that is grown within a laboratory setting to help identify which bacteria is present

30
New cards

Define sensitivity

bacterial culture is subjected to a variety of antibiotics to determine which are most effective against the pathogen present

31
New cards

What drugs have a PCN allergy contraindication?

Penicillin, cephalexin, meropenem, aztreonam

32
New cards

What drugs can cause photosensitivity?

sulfamethoxazole/trimethoprim, tetracycline, ciprofloxacin

33
New cards

What drugs require peak and trough monitoring?

Vancomycin & Gentamicin

34
New cards

What are the causes of oral candidiasis (thrush)?

35
New cards

What are treatments for oral candidiasis (thrush)?

36
New cards

What antibiotics have pregnancy as a contraindication?

Meropenem, Sulfamethoxazole/Trimethoprim 1st tri, Nitrofurantoin 3rd tri, Gentamicin, Tetracycline, Ciprofloxacin

37
New cards

What is the mechanism of action for penicillin?

bactericidal

38
New cards

What is the indication for penicillin?

bacterial infections (gram + cocci), strep throat, dental procedures

39
New cards

What are the adverse effects for penicillin?

nausea, vomiting, diarrhea, allergic reaction

40
New cards

What are the contraindications for penicillin?

PCN allergy, renal disease

41
New cards

What are special considerations for penicillin?

Administered parenterally, monitor up to 30 min, BUN/ Creatinine

42
New cards

What is the mechanism of action for cephalexin?

bactericidal

43
New cards

What is the indications for cephalexin?

broad spectrum, skin infections

44
New cards

What are the contraindications for cephalexin?

allergy, severe PCN allergy

45
New cards

What are the adverse effects for cephalexin?

nausea, vomiting, diarrhea, supra-infection

46
New cards

What special considerations does cephalexin have?

Monitor in people with renal impairment and bleeding disorders

47
New cards

What is the MOA of Meropenem?

bactericidal, destroys bacterial cell wall

48
New cards

What is the indication for meropenem?

broad spectrum, peritonitis, UTI

49
New cards

What are contraindications for meropenem?

severe PCN allergy, pregnancy

50
New cards

What are adverse effects of meropenem?

allergy, GI upset, supra-infection

51
New cards

What are special considerations for Meropenem?

IV only

52
New cards

What is the MOA of Aztreonam?

bactericidal, inhibits cell wall synthesis

53
New cards

What are the indications of aztreonam?

UTI, sepsis, respiratory infections, intra-abdominal infections, surgical infections

54
New cards

What are the contraindications of aztreonam?

severe pcn allergy, renal and liver disease

55
New cards

What are the adverse effects of aztreonam?

GI upset, diarrhea, allergy

56
New cards

What special considerations does aztreonam have?

parental administration only

57
New cards

What is the MOA for Vancomycin?

bactericidal, inhibits bacterial cell wall synthesis

58
New cards

What is the indication for Vancomycin?

staph. infections, MRSA, C.DIFF

59
New cards

What is the contraindication for Vancomycin?

allergy

60
New cards

What are the adverse effects of vancomycin?

Red man syndrome, nephrotoxicity, ototoxicity, phlebitis

61
New cards

What are special considerations to be taken with vancomycin?

monitor peak and trough, administer over 60 min to avoid RMS, Monitor BUN/Creatinine, Monitor hearing acuity

62
New cards

What is the MOA of fosfomycin?

inhibits bacterial cell wall synthesis

63
New cards

What is the indication for fosfomycin?

upper UTI

64
New cards

What are the contraindications of fosfomycin?

renal and liver disease

65
New cards

What are the adverse effects of fosfomycin?

GI upset, diarrhea, headache, vaginitis, drowsiness, allergy

66
New cards

What are special considerations for fosfomycin?

single dose for lower UTI, take on empty stomach

67
New cards

What is the MOA for tetracycline?

Inhibits bacterial protein synthesis

68
New cards

What is the indication for tetracycline?

broad spectrum, acne vulgaris, dental infections, STI, H. Pylori, Lyme disease, PCN allergy

69
New cards

What are the contraindications of tetracycline?

pregnancy, children under 8, kidney and liver disease

70
New cards

What are the adverse effects of tetracycline?

tooth discoloration, photosensitivity, esophageal ulceration, hepatotoxicity, supra-infection

71
New cards

What are special considerations for tetracycline?

don’t take with dairy, take on empty stomach

72
New cards

What is the MOA for erythromycin?

bacteriostatic, inhibits bacterial protein synthesis

73
New cards

What is the indication for erythromycin?

strep throat, PCN allergy, Diphtheria, STI

74
New cards

What are the conrtaindications for erythromycin?

QT prolongation, liver disease, caution with warfarin

75
New cards

What are the adverse effects of erythromycin?

QT prolongation and possible Torsade’s de Pointe, GI upset, Ototoxicity

76
New cards

What are special considerations with erythromycin?

monitor INR if used with Warfarin

77
New cards

What is the MOA for Gentamicin?

bactericidal, disrupts protein synthesis

78
New cards

What is the indications for gentamicin?

infections, UTI, Intra-abdominal infections, conjunctivitis

79
New cards

What are the adverse effects of gentamicin?

ototoxicity, nephrotoxicity, dizziness, nausea, vertigo

80
New cards

What are the special considerations of gentamicin?

monitor peak and trough, monitor hearing, monitor creatinine

81
New cards

What are the contraindications of gentamicin?

pregnancy and renal failure

82
New cards

What is the MOA of ciprofloxacin?

inhibit DNA replication

83
New cards

What is the indication for ciproloxacin?

broad spectrum, UTI, Pneumonia, osteomyelitis, soft tissue infection, anthrax exposure

84
New cards

What ist eh contraindications for ciprofloxacin?

under 18, pregnancy, use cautiously in geriatrics, renal disease, warfarin

85
New cards

What are the adverse effects of ciprofloxacin?

GI upset, Supra-infection, Tendonitis/ Rupture, photosensitivity, thrush

86
New cards

What are special considerations for ciprofloxacin?

risk of achille’s tendon rupture, monitor INR if used with warfarin

87
New cards

What is the MOA for metronidazole?

Disrupts cellular DNA

88
New cards

What is the indication for metronidazole?

C.diff

89
New cards

What is the contraindication for metronidazole?

alcohol, seizure disorder, warfarin

90
New cards

What are the adverse effects of metronidazole?

disulfiram-like reaction if combined with alcohol, metallic taste

91
New cards

What are the special considerations for metroidazole?

If client is on warfarin, monitor INR

92
New cards

What is the MOA of sulfamethoxazole/trimethoprim?

bactericidal, folic acid blocker

93
New cards

What is the indication for sulfamethoxazole/trimethoprim?

UTI, Pneumonia, otitis media

94
New cards

What is the contraindication of sulfamethoxazole/trimethoprim?

sulfa drug allergy, renal failure, avoid in 1st trimester

95
New cards

What are the adverse effects of sulfamethoxazole/trimethoprim?

steven-johnsons syndrome, C.Diff, bone marrow suppression, photosensitivity

96
New cards

What are the special considerations for sulfamethoxazole/trimethoprim?

monitor/report any skin rash while taking, avoid sun, monitor CBC

97
New cards

What is the MOA for nitrofurantoin?

bacteriostatic, damages DNA

98
New cards

What is the indication for nitrofurantoin?

lower UTI, recurrent UTIs

99
New cards

What is the contraindications for nitrofurantoin?

renal disease, avoid in 3rd trimester

100
New cards

What are the adverse effects of nitrofurantoin?

GI upset, anorexia, bone marrow suppression, hypersensitivity reaction