Blood Bank II Unit #1.2

Weak D Testing

reactions are negative or <2+ at IS phase

Weak D - Inherited Mutation

genetic mutation on type 1,2, and 3. causes decrease in number of D antigen expressed. D pos transfusion

Weak D - Position Effect

RHD is trans to RHCe. Normal amount of D antigen is expressed, but weakened expression. Transfusion D pos

Partial D

RBC lacks parts of D antigen. Allo-anti D can be made to missing part. Transfuse D neg

Del

extremely weak D expression. detectable only by elution/adsorption. Types as D neg on IS and IAT

Nonfunctional RHD

RHD alleles do not code full length polypeptide, no D antigen expressed

Modern Monoclonal Blend

blends of IgM and IgG monoclonal anti-D. Higher sesnitivity causing reactions at IS

Weak D Control

determines whether there was prior sensitization of pt RBC with IgG antibodies. if pos then inconclusive

Always preformed

Blood/organ/tissue donor, Rh neg infant born to Rh neg mom, Rh pos patient who now type Rh neg