Antibodies lecture 6

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Last updated 4:31 PM on 9/10/26
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13 Terms

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Antibody
Protein produced by cells of the immune system.
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Antigen
Ligand that is bound by an antibody.
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Antigen binding site
Region of an antibody where an antigen binds.
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How do antibodies help immune function?
They bind antigens.
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What determines which antigen an antibody binds?
The amino acid sequence in the antigen-binding site.
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How do antigens bind antibodies?
Through noncovalent interactions.
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Antibody structure
Y-shaped protein made of multiple polypeptide chains.
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What stabilizes antibody structure?
Disulfide bonds.
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What secondary structure is present in antibody domains?
Beta sheets.
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Do disulfide bonds directly bind an antigen?
No. Antigen binding is mediated by noncovalent interactions such as hydrogen bonds, ionic interactions, and van der Waals attractions.
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Antibody highest level of protein structure
Quaternary structure, because antibodies are made of multiple polypeptide chains.
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Why do antibodies have quaternary structure?
Their final functional protein is made from more than one polypeptide chain.
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What other structural features do antibodies have?
They contain multiple domains, beta sheets, and disulfide bonds that help stabilize the structure.