Non-gravid Ovary Pathology

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13 Terms

1
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What are the 3 main categories of ovarian disease?

Anomalous/congenital

Metabolic (cysts)

Neoplastic

2
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<p>What are the 2 most common congenital conditions of the ovary and give brief description.</p>

What are the 2 most common congenital conditions of the ovary and give brief description.

Ovarian hypoplasia

Ovarian dysgenesis - often linked to chromosomal abnormalities (monosomy or trisomy)

Ovaries are small and lack follicular activity

3
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4 places cysts in the ovarian parenchyma can derive from

  • anovulatory Graafian follicles (luteal & follicular cysts)

  • cystic corpora lutea

  • cystic rete ovarii

  • cysts of subsurface epithelial structures

Most cause no problems but some can interfere with normal reproductive cycles

4
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<p>What is this in a cow?</p>

What is this in a cow?

Follicular cyst

5
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<p>What are these in a cow</p>

What are these in a cow

Left = follicular cyst

Right = luteal cyst

6
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Behavioural and physiological changes associated with folicular cysts in cattle

Frequent intermittent oestrus

Nymphomania

Sexual quiescent/anoestrous

Follicular cysts can be 25-60mm

Steroidogenesis (oestrogens, progesterone, androgens)

7
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Signs associated with luteal cysts in cattle

Anoestrus

Thick, yellow lutinized wall)

Primarily progesterone production

8
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<p>What is this condition?</p>

What is this condition?

Cystic corpora lutea = variation of normal luteal structure

animal can be pregnant

9
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<p>What is this condition? What are associated clinical signs?</p>

What is this condition? What are associated clinical signs?

Cystic rete ovarii (guineapig)

  • bilateral non-pruritic alopecia

  • clitoral hypertrophy

  • nipple hyperkeratosis

  • behavioural changes

<p>Cystic rete ovarii (guineapig)</p><ul><li><p>bilateral non-pruritic alopecia</p></li><li><p>clitoral hypertrophy</p></li><li><p>nipple hyperkeratosis</p></li><li><p>behavioural changes</p></li></ul><p></p>
10
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Describe pathophysiology/pathogenesis of cystic subsurface epithelial structures

Peritoneal cells covering ovary can develop multiple (or a single) cysts

Can undergo papillary hyperplasia and neoplastic transformation

Usually adenomas but can be carcinomas

No hormones produced

11
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<p>What is this condition? Describe pathogenesis</p>

What is this condition? Describe pathogenesis

Papillary cystadenoma/cystadenocarcinoma (surface epithelium and SES tumour)

Neoplasia from surface epithelium covering ovary

12
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<p>What is this condition and associated clinical signs</p>

What is this condition and associated clinical signs

Granulosa cell tumour - most common ovarian tumour of the mare (sex cord stromal tumour)

Usually benign

Behavioural/reproductive abnormalities

  • Inhibin = lack of cycling in opposite ovary

  • Oestrogen = nymphomania, prolonged oestrus

  • Progesterone = anoestrus

  • Testosterone = stallion-like behaviour

Always increased levels of anti-Mullerian hormone

<p>Granulosa cell tumour - most common ovarian tumour of the mare (sex cord stromal tumour)</p><p>Usually benign</p><p>Behavioural/reproductive abnormalities</p><ul><li><p>Inhibin = lack of cycling in opposite ovary</p></li><li><p>Oestrogen = nymphomania, prolonged oestrus</p></li><li><p>Progesterone = anoestrus</p></li><li><p>Testosterone = stallion-like behaviour</p></li></ul><p>Always increased levels of anti-Mullerian hormone</p><p></p>
13
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<p>What is this condition?</p>

What is this condition?

Teratoma (germ cell tumour)