Remembering and Imagining

Hippocampus

Primarily involved in retrieval of episodic memories

Retrieval

Accessing information stored in LTM to conscious awareness in STM

Autobiographical events

Episodic memory involving episodic and semantic memory, retrieval from hippocampus

Alzheimers Disease

Neurodegenerative disease characterised by memory decline due to lesions forming predominantly in the hippocampus

Alzheimers Disease

Neurodegenerative disease characterised by memory decline due to lesions forming predominantly in the hippocampus

Amyloid plaques

Accumulated clumps of beta amyloid protein fragments between neural synapses, inhibiting communication.

neurofibrillary tangles

Tau protein accumulates and tangles, inhibiting transportation of essential substances

neurofibrillary tangles

Tau protein accumulates and tangles, inhibiting transportation of essential substances

Alzheimers brain

Alzheimers brains are smaller due to loss of neurons, leading to reduced brain matter.

Early Stage

Up to 75%of hippocampal neurons die, causing anterograde amnesia

Anterograde amnesia

Inability to form new episodic and semantic memories

Later Stage Amnesia

Damage spreads to the cerebral cortex, resulting in retrograde amnesia

Retrograde amnesia

Losing previously stored semantic, episodic and autobiographical memories and their retrieval

Final stage amnesia

Damage spreads to hind brain, affecting autonomic functions and leading to death