Osteoporosis

Alendronate (solid,liquid)

Usage: Osteoporosis

Side Effects:

• Remain upright 30m after taking

• Take 30 min before bood, beverage (exc: water), other med

Brand Name: Fosamax

Drug Class: Bisphophonates

Ibandronate (inj,solid)

Usage: Osteoporosis

Side Effects:

• Remain upright 60 minutes after taking

• Taken 60 min before food, beverage (exc:water), other meds

Brand Name: Boniva

Drug Class: Bisphosphonates

Risedronate (solid)

Usage:Osteoporosis

Side Effects:

• Take 30min before food, beverages (excep: water), meds

• Remain upright 30 min after taking med

Brand Name:Actonel

Drug Class: Bisphosphonates

Zoledronic Acid (inj)

Usage:

• Bone Cancer

• Osteoporosis

Side Effects:

• Avoid in pregant pt

• NIOSH med

Brand Name: Reclast

Drug Class: Bisphonates

Denosumab (inj)

Usage:

• Bone Cancer

• Osteoporosis

Side Effects:

• Avoid in pregant pt

• High-alert med

• Administered by healthcare profession

• Store in refrigerator

Brand Name: Prolia

Drug Class: RANKL Inhibitor

Abaloparatide (inj)

Usage: Osteoporosis

Side Effects:

• Inj site reaction (pain,redness)

• Store in refrigerator

Brand Name: Tymlos

Drug Class: Parathyroid Hormone Analogs

Teriparatide (inj)

Usage: Osteoporosis

Side Effects:

• Store in refrigerators until ready to use

• Lie down when administering

Brand Name: Forteo

Drug Class: Parathyroid Hormone Analogs

Raloxifene (solid)

• Usage:
  Breast Cancer Prophylaxis

• Osteoporosis

Side Effects:

• Avoid in pregnant pt/breastfeeding & history of blood clots

• Hot flashes

• NIOSH med

Brand Name: Evista

Drug Class: Selective Estrogen Receptor Modulators (SERMs)

Conjugated estrogens/bazedoxifene (solid)

Usage: Osteoporosis

Side Effects:

• Avoid in breast/ovarion cancer and cardiovascular issues

• Avoid smoking while on med

• Beers med

• NIOSH med

Brand Name: Duavee

Drug Class: Combination Drug Class

Bisphosphonates mechamism of action

Inhibit bone resorption by interfering with fuction of osteoclasts (cells responsible for breaking down bone)

RANKL Inhibitor Mechanism of Action

By inhibit the RANKLS and it Receptor, its was an molecules that signal bone resorption

Parathyroid hormone analogs Mechanims of Action

Mimics the parathryoid hormone, stimulated bone formation and increase bone mass

Selective Estrogen Receptor Modulators (SERMs)

Binding to the Estrogen leading to various body cell functions