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Varenicline MOA
partial a/B2 nicotinic agonist that stimulates dopamine to a much smaller degree than nicotine
Varenicline indications
smoking cessation
Varenicline dosage forms
oral
Varenicline administration
after eating and with a full glass of water
Varenicline major side effects
CV events, nausea, vomiting, disordered sleep, insomnia, irritability, neuropsychiatric events, seizures
Varenicline safety monitoring parameters
mental status changes
Varenicline efficacy monitoring parameters
abstinence from tobacco
Varenicline major interactions
alcohol, nicotine
Varenicline can cause
CNS depression (decreased mental alertness)
caution Varenicline use in pts with
renal impairment