CM Common Drugs

Atenolol (tenormin)

Beta Blocker

Metoprolol (Lopressor, Toprol)

Beta Blocker

Propanolol (inderal)

Beta Blocker

Beta Blocker Indications

HTN, CHF

Beta Blocker MOA

Decreased force and demand on heart

Prazosin (Minipress)

Alpha Blocker

Doxazosin (Cardura)

Alpha Blocker

Alpha Blocker Indications

HTN, CHF

Alpha Blocker MOA

Decrease vasoconstriction, increase vasodilation, decrease afterload, preload and demand on heart

Diltiazem (cardizem)

Calcium Channel Blocker- Nondihydropiridine

Verapamil (calan)

Calcium Channel Blocker- Nondihydropiridine

Calcium Channel Blocker MOA

Blocks constriction of coronary arteries

Amlodipine (norvasc)

Calcium Channel Blocker- Dihydropiridine

Nifedipine (procardia)

Calcium Channel Blocker- Dihydropiridine

Felodipine (plendil)

Calcium Channel Blocker- Dihydropiridine

Calcium Channel Blocker- Dihydropiridine SE

Increased risk of MI

Hydralzine (apresoline)

Vasodilator

Vasodilator Indications

Second-line drug when other HTN agents don’t work; emergency situations for CHF

Enalapril (Vasotract)

ACE Inhibitor

Fosinopril (monopril)

ACE Inhibitor

Lisinopril (Zestril)

ACE Inhibitor

Quinapril (acupril)

ACE Inhibitor

ACE Inhibitor Indications

HTN, CHF

ACE inhibitor SE

cough

ACE Inhibitor MOA

stops production of angiotensin II

NSAIDs _____(inhibit/potentiate) ACE Inhibitors

inhibit

Irebesartan (Avapro)

Angiotensin II Receptor Agonist

Isosartan (cozaar)

Angiotensin II Receptor Agonist

Valsartan (diovan)

Angiotensin II Receptor Agonist

Hydrochlorathiazide

Diuretic

Furosemide (lasix)

Diuretic

Bumetanide (bumex)

Diuretic

Diuretic SE

Depletion of potassium

Digoxin (lanoxin)

Cardiac Glycoside

Cardiac Glycoside MOA

increases myocardial contraction

Cardiac Glycoside Indications

CHF, A-fib

Quinidine (quinidex)

Antiarrhythmic

Procainamide (procan)

Antiarrhythmic

Amiodarone (cordarone)

Antiarrhythmic

Atorvastatin (lipitor)

Statin/antihyperlipidemia

Lovastatin (mevacor)

Statin/antihyperlipidemia

Simvastatin (zocor)

Statin/antihyperlipidemia

Statin SE

myopathy/rhabdomyalgia risk

Aspirin, ASA

Antiplatelet/Antithrombotic

Clopidrogel (plavix)

Antiplatelet/Antithrombotic

Ticlopicine (ticlid)

Antiplatelet/Antithrombotic

Antiplatelet/Antithrombotic Indications

Arterial thrombus control; prevention of CVA or MI

Heparin IV

Anticoagulant

Enzozaparin SQ (Lovenox)

Anticoagulant

Warafin PO

Anticoagulant

Anticoagulant Indications

Venous treatment of clots, used prophylactically after surgery or as treatment for PE/DVT

Stretokinase

Thrombolytic

tPa- tissue plasminogen activator

Thrombolytic

Thrombolytic Indications

emergency use for arterial clot; must be administered within 1-2 hours

nitrostat

Nitroglycerin SL

Isosorbide dinitrate SL (nitroquick)

Nitroglycerin SL

Nitroglycerin SL Indications

PRN use for angina

Nitroglycerin TRD (nitro-derm, nitro-dur

Nitroglycerin Transdermal Patch

Anti-HTN Common SE

* dizziness
* lightheadedness
* orthostatic hypotension

NSAIDs ____ (potentiate/inhibit) anticoagulants/antithrombotics

potentiate

Big Gun Drugs

1. Digoxin (lanoxin)- Digitalis
2. Warafin (coumadin)
3. Antiarrhythmic Drugs


1. Amiodarone (cordarone)
2. Procainamid (procan)
3. Quinidine (quinidex)

Why are big gun drugs a concern?

low TI→ patients very likely to receive toxic dose

Albuterol (proventil)

Beta 2 Agonist-- Rescue

Salmeterol (serevent)

Beta 2 Agonist-- Long-Acting

Beta 2 Agonist Indications

Asthma

Beta 2 Agonist MOA

Bronchodilation

Beta 2 Agonist. Common SE

tachycardia

Ipratropium (atrovent)

Anticholinergics

Anticholinergics SE

SLUD + tachycardia

Anticholinergic Indications

COPD

Anticholinergics MOA

blocks vagal parasympathetic tone to decrease resting bronchoconstriction

Flucticasone (flovent)

Glucocorticoid

Triamcinolone (amzacort)

Glucocorticoid

Fluisolide (aerobid)

Glucocorticoid

Glucocorticoid Inidcations

Decrease inflammation for COPD and asthma

Zafirlukast (accolate)

Leukotriene Modifier

Montelukast (singulair)

Leukotriene Modifier

Leukotriene Modifier Indications

COPD

Cromolyn (intal)

Cromone “mast cell stabilizer”

Cromone “mast cell stabilizer” Indications

COPD

Prednisolone (prelone)

Corticosteroid

Prednisone (deltasone)

Corticosteroid

Dexamethasone (decadron)

Corticosteroid

Hydrocortisone (cortef)

Corticosteroid

Cortisone (cortone)

Corticosteroid

Methylprednisone (medrol)

Corticosteroid

Corticosteroid Treatment Goal

decrease inflammation, inhibit inflammatory cells, suppress immune system

Corticosteroid Indications

endocrine replacement therapy, anti-inflammaorty agent, immunosuppressant agent

Corticosteroid SE

Immune System: __Immunosuppression__

Integumentary: __impaired wound healing__, bruising

GI: __peptic ulcer,__ gastritis

Muscular: __myopathy,__ loss of muscle mass, weakness

CV: __CHF,__ cardiac arrest, arrhythmias, cardiac enlargement, circulatory collapse, fat embolism, HTN, bradycardia

Metabolic: __hyperglycemia,__ diabetes

Skeletal: __osteoporosis,__ vertebral compression fx, femoral/humeral necrosis, pathologic fx, tendon rupture

Optic: __glaucoma__

Pediatric: __stunted growth__

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Naproxen (naprosyn)

NSAID

Piroxicam (feldene)

NSAID

Difunisol (dolobid)

NSAID

Ibuprofen (advil, motrin)

NSAID

Indomethacin (indocin)

NSAID

NSAID Properties

analgesic, anti-pyretic, anti-inflammatory, anti-coagulant

NSAID SE

* gastric irritation
* bleeding

Methotrexate (rheumatrext)

DMARD (Disease-Modifying Anti-Rheumatic Drug)

Cyclophosphamide (cytoxan)

DMARD (Disease-Modifying Anti-Rheumatic Drug)

Cyclosporine (neoral)

DMARD (Disease-Modifying Anti-Rheumatic Drug)

Azathiprine (imuran)

DMARD (Disease-Modifying Anti-Rheumatic Drug)