Urinary system drugs

Hydrochlorothiazide

chlorothiazide

hydroflumethiazide

Act directly on distal convoluted tubules. Block Na reabsorption and promote CI ion excretion. long term effects lead to hypokalemia

Furosemide

Block absorption of CI, K , Ca, H , Mg, bicarbonate ions. Causes diuresis. Treat CHF, pulmonary edema and hypertenstion

Spironolactone

Triamterene

Amiloride

Act on Distal convoluted tubules. Promote Na and H2O excretion and K retention

Mannitol

Increase the osmolality of filtrate in the renal tubules. Results in the excretion of Na, CI, K & H2O

ABOVE

Have an antihypertensive effect by promoting Na & H2O loss

Enalapril

Captopril

Lisinopril

Benazepril

Treat hypertension by blocking conversion of angiotensin 1 to angiotensin 2

Diltiazem

Verapamil

Nifedipine

Blocks influx of Ca ions into myocardial cells= inhibition of cardiac & vascular smooth muscle contractility

Hydralazine

Relaxes smooth muscles of blood vessels causing vasodilation

Propranolol

nonselective beta blockers result in bradycardia & bronchoconstriction

Phenoxybenzamine

Prazosin

block circulating epinephrine or norepinephrine form binding to receptors

Bethanechol

(gets rid of urine) bind to receptors on sm muscles allowing Na & Ca to ent4er cells. influx of Na & Ca allows for muscle contraction.

Propantheline

( keep urine in) blocking the binding of Ach to its receptor sites & causes muscle relaxation

Estrogen

Sex hormones contribute to the maintenance of urethral muscle tone ( lack of hormones cause dribbling or urine)

Testosterone

Treat hormone responsive incontinence in male dogsO

Phenylpropanolamine

( brand name PPA, Proin) Inc. tone of urethral sphincters

Dexatrim

Inc. tone of urethral sphincters

Ephedrine

Inc. tone of urethral sphincters

Pseudoephedrine

Inc. tone of urethral sphincters. Closure of urinary bladder neck