HISTONE H3 VARIANTS (Page 36)

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Last updated 2:11 PM on 6/19/26
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6 Terms

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; [How many genes encode histone proteins in humans and how many H3 variants are there?]

In humans, 15 different genes encode one of 3 canonical histone proteins (H3.1, H3.2, and H3.3), providing enormous redundancy in production of these critical proteins.

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; [Where is H3.1 incorporated?]

H3.1 is incorporated into nucleosomes genome-wide without site-specific preferences.

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; [Where is H3.3 selectively incorporated?]

H3.3 is incorporated selectively at actively transcribed regions (promoters and enhancers) and heterochromatin.

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; [What is CENP-A?]

A non-canonical H3 variant with a critical role in demarking centromeres during mitosis.

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; [Are there other H3 variants?]

Yes, there are many other histone H3 protein variants that have distinct function