Amino Acids- Biochemistry

A Ala Alanine

F Phe Phenylalanine

K Lys Lysine

P Pro Proline

T Thr Threonine

C Cys Cysteine

G Gly Glycine

L Leu Leucine

Q Gln Glutamine

V Val Valine

D Asp Aspartate

H His Histidine

M Met Methionine

R Arg Arginine

W Trp Tryptophan

E Glu Glutamate

I Ile Isoleucine

N Asn Asparagine

S Ser Serine

Y Tyr Tyrosine

COO^- pKa

~2 AA ~3 proteins

H₃N⁺ pKa

~9.5 AA ~8 proteins

Asp pKa

3.7

Glu pKa

4.3

His

6

Cys

8.2

Tyr

10.1

Lys

10.5

Arg

12.5

Nucleophiles

-aspartate

-glutamate

-serine (after deproton)

-threonine (after deproton)

-lysine (after deproton)

-cysteine (after deproton)

nonpolar, aliphatic R groups

-glycine

-alanine

-proline

-valine

-leucine

-isoleucine

-methionine

aromatic R groups

-phenylalanine

-tyrosine

-tryptophan

polar + uncharged

-serine

-threonine

-cysteine

-asparagine

-glutamine

positive + charged

-lysine

-histidine

-arginine

negatively charged

-aspartate

-glutamate