Introduction to Hematology Practice Flashcards

Fill-in-the-blank review flashcards covering foundational hematology topics including blood components, acute phase reactants, RBC/WBC pathology, blood typing, and cell morphology based on lecture notes.

Blood plasma minus the clotting factors is known as __________.

serum

Acute phase reactants (APRs) change their serum concentration by greater than __________ in response to inflammatory cytokines.

$$25\%$$

B lymphocytes are produced and mature in the __________.

bone marrow

T lymphocytes are produced in the bone marrow and migrate to mature in the __________.

thymus

Heme is composed of four pyrrole rings held together by iron in its reduced __________ form.

ferrous ($Fe^{2+}$)

One molecule of hemoglobin contains four heme units and can bind up to __________ molecules of oxygen.

$$4$$

When hemoglobin is degraded, the cleaved protoporphyrin complex gives rise to the waste product __________.

bilirubin

A high red cell distribution width (RDW) suggests a divergent population of red cells of different sizes, a condition known as __________.

anisocytosis

The normal mean cell hemoglobin concentration (MCHC) value reported on a CBC is __________.

$$34 \pm 2\,g/dl$$

Fragmented erythrocytes indicative of intravascular destruction are called __________.

schistocytes

Teardrop-shaped red blood cells are commonly found in __________, a response to bone marrow failure.

extramedullary hematopoiesis (EMH)

In hereditary spherocytosis, red cell membrane instability is caused by a lack of the cytoskeletal membrane protein __________.

spectrin

Red blood cells stacking together in long chains is known as __________, which increases the erythrocyte sedimentation rate (ESR).

rouleaux

Howell-Jolly bodies represent inclusions of nuclear __________ remnants.

chromatin (DNA)

Basophilic stippling in red blood cells consists of ribosomal precipitates commonly seen in __________ poisoning.

lead

Heinz bodies represent denatured hemoglobin and are characteristic of __________ deficiency.

G6PD

An immature neutrophil with a uni-lobar nucleus seen in peripheral blood is called a __________.

band cell

Neutrophils with 5 or more nuclear lobes are hyper-segmented and typically indicate __________ deficiency.

vitamin B12 or folate

A non-leukemic elevated white blood cell count greater than 50,000 is known as a __________.

leukemoid reaction

In the NAACP mnemonic for causes of eosinophilia, the letter 'C' stands for __________.

collagen vascular disease

Basophilic leukocytosis is a rare phenomenon most often associated with __________.

chronic myelogenous leukemia (CML)

Monocytes are the largest cells in the blood and migrate into tissues to become __________.

macrophages

Innate anti-A and anti-B immunoglobulins belong to the __________ class and do not easily cross the placenta.

IgM

The anti-D antibody is an immunoglobulin of the __________ class, which readily crosses the placenta.

IgG

Transfusing 1 unit of packed red blood cells (PRBCs) increases hematocrit by __________.

$$3\%$$

Damaged lymphocytes known as 'smudge cells' on a peripheral blood smear are diagnostic of __________.

chronic lymphocytic leukemia (CLL)

Inclusions of incompletely degraded hemoglobin pigment known as __________ inside monocytes are a clear sign of malaria.

hemozoin