cholesterol drugs

atorvastatin: brand

lipitor

atorvastatin: lipitor: class

HMG-CoA reductase inhibitor

atorvastatin: lipitor: indications

Hyperlipidemia, primary/secondary prevention of ASCVD [Atherosclerotic Cardiovascular Disease], familial hypercholesterolemia

atorvastatin: lipitor: MOA

Inhibits HMG-CoA → mevalonate → ↓ cholesterol synthesis; ↑ LDL receptor activity

atorvastatin: lipitor: contradications

Breastfeeding, active liver disease

atorvastatin: lipitor: BBW

None

atorvastatin: lipitor: common ADRs

Diarrhea, myopathy

atorvastatin: lipitor: rare ADRs

Hepatotoxicity, rhabdomyolysis

atorvastatin: lipitor: counseling

Lowers bad cholesterol, raises good cholesterol; tell doctor if muscle pain

ezetimibe: brand

zetia

ezetimibe: zetia: class

Cholesterol absorption inhibitor

ezetimibe: zetia: indications

Hyperlipidemia, familial hypercholesterolemia

ezetimibe: zetia: MOA

Inhibits NPC1L1 receptor → ↓ intestinal cholesterol absorption → ↓ hepatic cholesterol stores → ↑ clearance

ezetimibe: zetia: contraindications

Gallbladder disease, severe hepatic dysfunction

ezetimibe: zetia: BBW

None

ezetimibe: zetia: common ADRs

None

ezetimibe: zetia: rare ADRs

Rhabdomyolysis, hepatotoxicity

ezetimibe: zetia: counseling

Lowers bad cholesterol, raises good cholesterol; contact doctor if muscle pain develops

colesevelam: brand

welchol

colesevelam: welchol: class

Bile acid sequestrant

colesevelam: welchol: indications

Hyperlipidemia

colesevelam: welchol: MOA

Binds bile acids → excretion → ↑ conversion of cholesterol → bile acids

colesevelam: welchol: contraindications

TG >500 mg/dL, bowel obstruction, history of hypertriglyceridemia-induced pancreatitis

colesevelam: welchol: BBW

None

colesevelam: welchol: common ADRs

Constipation

colesevelam: welchol: rare ADRs

Bowel obstruction, pancreatitis

colesevelam: welchol: counseling

Lowers bad cholesterol, raises good cholesterol; take with food; mix granules with water or take capsules with water

fenofibrate: brand

fenoglide, antara

fenofibrate: fenoglide, antara: class

Fibric acid

fenofibrate: fenoglide, antara: indications

Hyperlipidemia, hypertriglyceridemia

fenofibrate: fenoglide, antara: MOA

Activates PPARα → ↑ lipolysis → ↓ triglycerides; induces lipoprotein lipase, ↓ apoC-III

fenofibrate: fenoglide, antara: contraindications

Gallbladder disease

fenofibrate: fenoglide, antara: BBW

None

fenofibrate: fenoglide, antara: common ADRs

↑ transaminases

fenofibrate: fenoglide, antara: rare ADRs

Rhabdomyolysis (esp. with statin), hepatotoxicity

fenofibrate: fenoglide, antara: counseling

Lowers bad cholesterol, raises good; follow specific directions (some require food); report muscle pain

niacin: brand

niaspan

niacin: niaspan: class

Antilipidemic

niacin: niaspan: indications

Hyperlipidemia

niacin: niaspan: MOA

↑ lipoprotein lipase; ↓ FFA release; ↑ chylomicron clearance; ↓ VLDL & LDL synthesis

niacin: niaspan: contraindications

Severe hepatic dysfunction, peptic ulcer disease

niacin: niaspan: BBW

None

niacin: niaspan: common ADRs

Flushing, headache

niacin: niaspan: rare ADRs

Rhabdomyolysis, hepatotoxicity

niacin: niaspan: counseling

Lowers bad cholesterol, raises good; titrate to dose; avoid alcohol & spicy foods; take aspirin 30 min prior to reduce flushing

omega-3-ethyl esters: brand

lovaza

omega-3 ethyl esters: lovaza: class

Omega-3 fatty acids

omega-3 ethyl esters: lovaza: indications

Hyperlipidemia, hypertriglyceridemia

omega-3 ethyl esters: lovaza: MOA

↓ triglyceride-rich LDL; ↑ beta-oxidation; ↓ hepatic TGs

omega-3 ethyl esters: lovaza: contraindications

Sensitivity to shellfish, fish, or drug

omega-3 ethyl esters: lovaza: BBW

none

omega-3 ethyl esters: lovaza: common ADRs

Diarrhea, fishy breath/taste, burping

omega-3 ethyl esters: lovaza: rare ADRs

Elevated LFTs

omega-3 ethyl esters: lovaza: counseling

Lowers bad cholesterol; take with food